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Pharmaceutical composition

DC CAFC
  • US 7,608,610 B2
  • Filed: 02/02/2009
  • Issued: 10/27/2009
  • Est. Priority Date: 04/19/2002
  • Status: Expired due to Fees
First Claim
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1. A method for maintaining a therapeutically effective concentration of testosterone in the blood serum of a male for treating hypogonadism which comprises transdermally delivering to the male by applying to the skin a composition which is in the form of a topical gel, which has a viscosity of about 500 to about 20,000 cps and a pH of about 3 to about 9, and comprises:

  • (A) about 0.1 to about 5 wt. % of testosterone;

    (B) about 0.5 to about 25 wt. % of a macrocyclic enhancer selected from the group consisting of 3-methylcyclopentadecanone, 9-cycloheptadecen-1-one, cyclohexadecanone, cyclopentadecanone, oxacyclohexadecan-2-one and mixtures thereof (C) about 0.1 to about 10 wt. % of a thickening agent;

    (D) a mixture of solvents which include about 40 wt. % to about 80% of ethanol.

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