Dual variable domain immunoglobulin and uses thereof

  • US 7,612,181 B2
  • Filed: 08/18/2006
  • Issued: 11/03/2009
  • Est. Priority Date: 08/19/2005
  • Status: Expired due to Fees
First Claim
Patent Images

1. A binding protein comprising four polypeptide chains, wherein two polypeptide chains comprise VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first heavy chain variable domain, VD2 is a second heavy chain variable domain, C is a heavy chain constant domain, X1 is a linker with the proviso that it is not CH1, and X2 is an Fc region;

  • and two polypeptide chains comprise VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first light chain variable domain, VD2 is a second light chain variable domain, C is a light chain constant domain, X1 is a linker with the proviso that it is not CH1, and X2 does not comprise an Fc region; and

    n is 0 or 1;

    wherein said four polypeptide chains of said binding protein form four functional antigen binding sites.

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