Devices and methods for disruption and removal of luminal occlusions
First Claim
1. A method for removal of thrombus material from an intracranial blood vessel of a human subject, using a device having a balloon-activated compartment, said method comprising:
- (a) inserting the device into the intracranial blood vessel of the subject, wherein the device comprises a rod, an elastomeric sheath that ensheaths at least a segment of the rod, and an expandable balloon for expanding the elastomeric sheath, wherein the expandable balloon, upon initiation of expansion, provides radial pressure to a portion of the elastomeric sheath, causing an adjacent segment of the elastomeric sheath to be displaced outwardly away from the rod segment, thereby forming the compartment beneath the displaced elastomeric sheath segment, wherein the displaced elastomeric sheath segment comprises a plurality of slits that expand upon expansion of the balloon, and wherein the compartment has a volume that is larger than the space occupied by the expanded balloon;
(b) expanding the balloon;
(c) capturing the thrombus material within the compartment, wherein said capturing of the thrombus material includes;
moving the device within the blood vessel;
bringing the displaced elastomeric sheath segment into contact with the thrombus material; and
causing the thrombus material to pass through a slit of the displaced elastomeric sheath segment;
(d) at least partially collapsing the balloon, thereby collapsing the compartment; and
(e) withdrawing the device from the blood vessel.
1 Assignment
0 Petitions
Accused Products
Abstract
The subject invention pertains to an elastic sheath, device, and methods for disrupting and/or removing occlusive material from lumens, particularly biological lumens, such as the vasculature, ureter, urethra, fallopian tubes, bile duct, intestines, and the like. The subject invention provides for effective disruption and removal of occlusive material, such as a thrombus, from the body lumen with minimal risk of injury to the lumen wall. Advantageously, the invention can be used to achieve a high degree of removal while minimizing the amount of occlusive material that is released into the body lumen. The subject invention further pertains to methods for disrupting and removing occlusive material from a biological lumen. In another aspect, the present invention concerns a device useful as an in vitro model of luminal occlusion and methods for using the device to test the efficacy of devices and methods for treating luminal occlusions.
211 Citations
28 Claims
-
1. A method for removal of thrombus material from an intracranial blood vessel of a human subject, using a device having a balloon-activated compartment, said method comprising:
-
(a) inserting the device into the intracranial blood vessel of the subject, wherein the device comprises a rod, an elastomeric sheath that ensheaths at least a segment of the rod, and an expandable balloon for expanding the elastomeric sheath, wherein the expandable balloon, upon initiation of expansion, provides radial pressure to a portion of the elastomeric sheath, causing an adjacent segment of the elastomeric sheath to be displaced outwardly away from the rod segment, thereby forming the compartment beneath the displaced elastomeric sheath segment, wherein the displaced elastomeric sheath segment comprises a plurality of slits that expand upon expansion of the balloon, and wherein the compartment has a volume that is larger than the space occupied by the expanded balloon; (b) expanding the balloon; (c) capturing the thrombus material within the compartment, wherein said capturing of the thrombus material includes; moving the device within the blood vessel; bringing the displaced elastomeric sheath segment into contact with the thrombus material; and causing the thrombus material to pass through a slit of the displaced elastomeric sheath segment; (d) at least partially collapsing the balloon, thereby collapsing the compartment; and (e) withdrawing the device from the blood vessel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
-
Specification