Method of reducing interferences in an electrochemical sensor using two different applied potentials
First Claim
1. A method of reducing interferences in an electrochemical sensor having a sample chamber with first and second working electrodes disposed in the chamber, the working electrodes including a reagent disposed thereon, the method comprising:
- contacting a sample of physiological fluid with the working electrodes and reagent, the physiological fluid including at least an analyte disposed therein;
applying a first potential to the first working electrode to initiate a chemical reaction;
applying a second potential to the second working electrode to initiate a chemical reaction, wherein said second potential is greater than the absolute value of said first potential;
measuring a first current, at said first working electrode, which comprises an analyte current and an interfering compound current;
measuring a second current, at said second working electrode, which comprises an analyte overpotential current and an interfering compound overpotential current, wherein said analyte overpotential current has a first directly proportional relationship to said analyte current, the first directly proportional relationship comprising
X×
A1=A2 where X is said analyte voltage effect factor derived from calibration test data of the sensor, A1 is said analyte current, and A2 is said analyte overpotential current and, wherein said interfering compound overpotential current has a second directly proportional relationship to said interfering compound current, the second directly proportional relationship is
Y×
I1=I2 where Y is said interfering compound voltage effect factor, I1 is said interfering compound current, and I2 is said interfering compound over potential current; and
calculating a corrected current value representative of an analyte concentration of the physiological fluid using an equation which is a function of said first current, said second current, said first directly proportional relationship, and said second directly proportional relationship.
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Abstract
The present invention is directed to a method of reducing the effects of interfering compounds in the measurement of analytes and more particularly to a method of reducing the effects of interfering compounds in a system wherein the test strip utilizes two or more working electrodes. In one embodiment of the present invention, a first potential is applied to a first working electrode and a second potential, having the same polarity but a greater magnitude than the first potential, is applied to a second working electrode.
152 Citations
6 Claims
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1. A method of reducing interferences in an electrochemical sensor having a sample chamber with first and second working electrodes disposed in the chamber, the working electrodes including a reagent disposed thereon, the method comprising:
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contacting a sample of physiological fluid with the working electrodes and reagent, the physiological fluid including at least an analyte disposed therein; applying a first potential to the first working electrode to initiate a chemical reaction; applying a second potential to the second working electrode to initiate a chemical reaction, wherein said second potential is greater than the absolute value of said first potential; measuring a first current, at said first working electrode, which comprises an analyte current and an interfering compound current; measuring a second current, at said second working electrode, which comprises an analyte overpotential current and an interfering compound overpotential current, wherein said analyte overpotential current has a first directly proportional relationship to said analyte current, the first directly proportional relationship comprising
X×
A1=A2where X is said analyte voltage effect factor derived from calibration test data of the sensor, A1 is said analyte current, and A2 is said analyte overpotential current and, wherein said interfering compound overpotential current has a second directly proportional relationship to said interfering compound current, the second directly proportional relationship is
Y×
I1=I2where Y is said interfering compound voltage effect factor, I1 is said interfering compound current, and I2 is said interfering compound over potential current; and calculating a corrected current value representative of an analyte concentration of the physiological fluid using an equation which is a function of said first current, said second current, said first directly proportional relationship, and said second directly proportional relationship. - View Dependent Claims (2, 3, 4, 5, 6)
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Specification