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Devices for intrabody delivery of molecules and systems and methods utilizing same

  • US 7,621,905 B2
  • Filed: 08/12/2003
  • Issued: 11/24/2009
  • Est. Priority Date: 12/30/1997
  • Status: Expired due to Fees
First Claim
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1. A device for controlled release of molecules comprising:

  • (a) a device body having at least one reservoir therein for containing the molecules, said at least one reservoir being formed with a barrier impermeable to the molecules thereby preventing release thereof from said at least one reservoir;

    (b) at least one acoustic transducer being attached to, or forming a part of, said device body, said at least one acoustic transducer being for converting an acoustic signal received thereby into an electrical signal; and

    (c) an acoustic switch coupled between the at least one acoustic transducer and an energy storage device, the energy storage device adapted to supply current to an electrical circuit operably coupled to the at least one reservoir upon the acoustic transducer receiving an acoustic wake-up signal from an acoustic energy source, the acoustic switch configured to actuate the electrical circuit between a passive mode in which the current is limited from flowing from the energy storage device to the electrical circuit, and an active mode that allows current to flow from the energy storage device to the electrical circuit, wherein in the active mode current flows from the energy storage device to the electrical circuit leading to barrier permeabilization and therefore release of the molecules from the at least one reservoir.

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