Method of and system for predicting dose delivery

• US 7,639,853 B2
• Filed: 07/21/2006
• Issued: 12/29/2009
• Est. Priority Date: 07/22/2005
• Status: Active Grant

• Current Assignee: TomoTherapy Incorporated (Accuray Incorporated)
• Original Assignee: TomoTherapy Incorporated (Accuray Incorporated)
• Inventors: Ruchala, Kenneth J., Lu, Weiguo, Schnarr, Eric, Mackie, Thomas R., Hughes, John H., Haimerl, Jason, Kapatoes, Jeffrey M., Olivera, Gustavo H.
• Primary Examiner(s): Strege; John B
• Application Number:
  US11/459,066
• Publication Number:
  US 20070041495A1
• Time in Patent Office: 1,257 Days
• Field of Search: 382/128, 382/131, 600/427
• US Class Current: 382/128
• CPC Class Codes: A61N 5/103 Treatment planning systems
• CPC Class Codes: A61N 5/1038 taking into account previously administered plans applied to the same patient, i.e. adaptive radiotherapy
• CPC Class Codes: A61N 5/1042 with spatial modulation of the radiation beam within the treatment head
• CPC Class Codes: A61N 5/1048 Monitoring, verifying, controlling systems and methods
• CPC Class Codes: A61N 5/1049 for verifying the position of the patient with respect to the radiation beam
• CPC Class Codes: A61N 5/1065 Beam adjustment
• CPC Class Codes: A61N 5/1069 Target adjustment, e.g. moving the patient support

Abstract

A system and method of predicting a radiation dose to be delivered to a patient. The method includes the acts of generating a first image of at least a portion of the patient, defining a treatment plan for the patient, generating a second image of at least a portion of the patient while the patient is substantially in a treatment position, updating the patient profile with the second image, and predicting the radiation dose to be delivered to the patient based upon the patient profile and the treatment plan.

Claims

1. A method of predicting a radiation dose delivered to a patient in the delivery of a treatment plan to the patient, the patient having a profile, the method comprising:

generating a first image of at least a portion of the patient;

defining a treatment plan for the patient;

generating a second volumetric image of at least a portion of the patient while the patient is substantially in a treatment position;

updating the patient profile with the second image; and

calculating using a computer the radiation dose to be delivered to the patient based upon the patient profile and the treatment plan.

2. A method as set forth in claim 1 wherein the profile is determined at least in part by the actual or intended patient position.

3. A method as set forth in claim 1 wherein the patient profile includes data related to a device that delivers radiation therapy, and wherein the device data is used to predict the radiation dose to be delivered to the patient.

4. A method as set forth in claim 1 wherein the patient profile includes motion data.

5. A method as set forth in claim 1 and further comprising evaluating past data to determine a combination of known dose delivered and predicted dose to be delivered based on the patient profile.

6. A method as set forth in claim 1 and further comprising collecting data during delivery of the treatment plan and comparing the predictive dose to the actual dose delivered to the patient.

7. A method as set forth in claim 1 further comprising changing patient position at least partially in response to the predictive dose.

8. A method as set forth in claim 1 wherein the treatment plan is changed in response to the predictive dose.

9. A method as set forth in claim 7 wherein the patient position is changed during treatment.

10. A method as set forth in claim 7 wherein the patient position is changed after treatment for subsequent treatments.

11. A method as set forth in claim 7 wherein the patient position is changed based on the expected biological effect of the predictive dose delivered.

12. A method as set forth in claim 1 wherein predicting dose to be delivered includes the use of deformable registration.

13. A method as set forth in claim 12 wherein deformable registration is used to identify contours of patient structures.

14. A method as set forth in claim 12 wherein deformable registration is used to determine dose accumulation.

15. A method as set forth in claim 1 further comprising generating a real-time, running predicted dose.

16. A method as set forth in claim 15 and further comprising using feedback to adjust the treatment plan or patient position based on the real-time, running predicted dose.

17. A method as set forth in claim 1 and further comprising acquiring data relating to clinical dose delivered and patient effect, and applying a biological model that relates the predictive dose to the patient effect.

18. A method of determining a radiation dose to be delivered to a patient, the method comprising:

generating a treatment plan for the patient;

acquiring a volumetric image of at least a portion of the patient while the patient is substantially in the treatment position;

calculating using a computer a plurality of doses that would be delivered to the patient for each of a plurality of patient profiles, each patient profile including the acquired image; and

selecting one of the patient profiles for delivery of the treatment plan.

19. A method as set forth in claim 18 wherein the patient profile includes position data.

20. A method as set forth in claim 18 wherein the patient profile includes motion data.

21. A method as set forth in claim 18 further comprising registering the patient using the acquired image and an image from the treatment plan.

22. A method of determining a radiation dose to be delivered to a patient, the method comprising:

delivering radiation to a patient according to a predetermined treatment plan;

acquiring a volumetric image of at least a portion of the patient during delivery of the radiation;

calculating using a computer a radiation dose while the radiation is being delivered, the radiation dose based on at least in part on the acquired image; and

determining whether to modify delivery of the radiation while the radiation is being delivered.

23. A method as set forth in claim 22 and further comprising modifying the treatment plan in response to the calculated radiation dose.

24. A method as set forth in claim 22 and further comprising adjusting a position of the patient in response to the calculated radiation dose.

25. A method as set forth in claim 22 and further comprising stopping the delivery of the radiation in response to the calculated radiation dose.