Methods of treating medical conditions by neuromodulation of the cerebellar pathways

• US 7,640,063 B2
• Filed: 05/04/2005
• Issued: 12/29/2009
• Est. Priority Date: 05/04/2004
• Status: Active Grant

• Current Assignee: Cleveland Clinic Foundation
• Original Assignee: Cleveland Clinic Foundation
• Inventors: Machado, Andre, Rezai, Ali R.
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): Gedeon; Brian T
• Application Number:
  US11/121,005
• Publication Number:
  US 20050283200A1
• Time in Patent Office: 1,700 Days
• Field of Search: 607/45
• US Class Current: 607/45
• CPC Class Codes: A61N 1/36017 with leads or electrodes penetrating the skin
• CPC Class Codes: A61N 1/36025 for treating a mental or cerebral condition
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: G16H 20/30 relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
• CPC Class Codes: G16H 20/40 relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture

Abstract

Methods of treating various medical conditions by neuromodulation of target sites of a cerebello-thalamo-cortical pathway and/or a cortical-ponto-cerebellar pathway. Such medical conditions include unilateral motor deficits, movement disorders, psychiatric disorders, epilepsy, speech or cognitive deficits associated with hemispheric lesions, visual deficits associated with hemispheric lesions, learning disorders associated with hemispheric lesions, vertigo and/or dizziness, gait disturbances, hereditary/genetic disorders, congenital malformations, infectious disease, degenerative disorders, autoimmune disorders, and metabolic disorders. A method of enhancing memory, learning and/or cognitive capacity in a normal individual by stimulating a target site of a cerebello-thalamo-cortical pathway and/or a cortical-ponto-cerebellar pathway is also provided.

Claims

1. A method of treating a medical condition resulting from a stroke or a traumatic etiology comprising:

placing a therapy delivery device on a target site, the target site selected from the group consisting of at least one of a deep cerebellar target site;

a thalamic nucleus target site that is within the cerebello-thalamo-cortical pathway, the thalamic nucleus target site including a projection from a deep cerebellar nucleus and including a projection to the cerebral cortex; and

projections from the cerebellum to the thalamus; and

activating the therapy delivery device to deliver a therapy signal to the target site to treat the medical condition resulting from the stroke or the traumatic etiology.

2. The method of claim 1, wherein the medical condition results from the stroke.

3. The method of claim 1, wherein the medical condition results from the traumatic etiology.

4. The method of claim 1, wherein the target site is the deep cerebellar target site.

5. The method of claim 1, wherein activating the therapy delivery device comprises initiating delivery of a therapy signal to the target site and adjusting parameters of the therapy signal to treat the medical condition resulting from the stroke or the traumatic etiology.

6. The method of claim 1, wherein the target site is a thalamic nucleus target site that is within the cerebello-thalamo-cortical pathway, the thalamic nucleus target site including a projection from a deep cerebellar nucleus and including a projection to the cerebral cortex.

7. The method of claim 1, wherein the target site is a projection from the cerebellum to the thalamus.