Wearable blood pressure sensor and method of calibration

• US 7,641,614 B2
• Filed: 08/22/2006
• Issued: 01/05/2010
• Est. Priority Date: 08/22/2005
• Status: Active Grant

• Current Assignee: Massachusetts Institute of Technology
• Original Assignee: Massachusetts Institute of Technology
• Inventors: Shaltis, Phillip, Asada, Haruhiko H., McCombie, Devin B., Reisner, Andrew T.
• Primary Examiner(s): Nasser; Robert L
• Application Number:
  US11/508,123
• Publication Number:
  US 20070055163A1
• Time in Patent Office: 1,232 Days
• Field of Search: 600481-507
• US Class Current: 600/485
• CPC Class Codes: A61B 2562/0219 Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
• CPC Class Codes: A61B 5/02225 using the oscillometric method
• CPC Class Codes: A61B 5/02233 Occluders specially adapted therefor tourniquets A61B17/132
• CPC Class Codes: A61B 5/02255 the pressure being controlled by plethysmographic signals, e.g. derived from optical sensors
• CPC Class Codes: A61B 5/11 Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb for measuring pulse A61B5/02 ;A61B5/1038 takes precedence; motion detection to correct for motion artifacts in physiological signals A61B5/721
• CPC Class Codes: A61B 5/6824 Arm or wrist
• CPC Class Codes: A61B 5/6826 Finger
• CPC Class Codes: A61B 5/6838 Clamps or clips

Abstract

Methods and apparatus for measuring arterial blood pressure at an extremity of a subject. Arterial blood pressure is derived from a circulatory measurement performed on an extremity of a subject and the circulatory measurement is normalized to account for the instantaneous vertical displacement of the extremity. The vertical displacement of the extremity relative to the heart of the subject is obtained using the angular orientation of the subject'"'"'s extremity. An improved photoplethysmograph can discriminate light traversing the extremity from ambient light on the basis of differential response. The apparatus may have a conducting polymer actuator for applying pressure to the extremity of the subject. A pulsatile waveform from the photoplethysmographic signal may be obtained at a plurality of externally applied pressures to calibrate the photoplethysmograph.

Claims

1. A method for performing a circulatory measurement on an extremity of a subject, the method comprising:

measuring a plethysmographic signal of a plethysmographic sensor disposed on the extremity of the subject at a plurality of heights of the sensor, relative to the heart of the subject, and at a plurality of externally applied pressures at each height of the sensor;

while measuring the plethysmographic signal, using a solid protrusion to externally apply a focal pressure to the extremity of the subject, the focal pressure having a value that may vary;

determining a relationship characterizing variation of the plethysmographic signal with the plurality of heights of the sensor and the plurality of externally applied pressures; and

deriving an arterial blood pressure feature based on at least the relationship characterizing variation of the plethysmographic signal with the plurality of heights of the sensor and the plurality of externally applied pressures, and on an instantaneously measured plethysmographic signal and height of the sensor relative to the heart of the subject.

2. A method in accordance with claim 1, further comprising:

modeling the relationship of a derived arterial pressure to the plethysmographic signal by fitting parameters of a specified functional relationship.

3. A method in accordance with claim 1, further comprising:

modeling the relationship of a derived mean arterial pressure to a peak plethysmographic signal by fitting parameters of a specified functional relationship.

4. A method in accordance with claim 1, wherein the plethysmographic signal is a photoplethysmographic signal.

5. A method in accordance with claim 1, wherein the focal pressure is additionally varied by means of an inflatable cuff.

6. A method in accordance with claim 1, wherein the focal pressure is additionally varied by means of a band using a polymer actuator.

7. A method in accordance with claim 1, wherein measurement of a plurality of heights of the sensor is derived from at least one angular displacement of the extremity.

8. A method in accordance with claim 7, wherein the at least one angular displacement of the extremity is obtained by means of an accelerometer.

9. A method in accordance with claim 1, further comprising:

removing spurious data points from the plethysmographic signal.

10. A method in accordance with claim 1, further comprising:

removing oscillations between beats of the heart from the plethysmographic signal.

11. A method in accordance with claim 1, further comprising:

deriving a systolic pressure by multiplying a peak plethysmographic signal by a specified factor.

12. A method in accordance with claim 11, wherein the factor is approximately 0.5.

13. A method in accordance with claim 1, further comprising:

deriving a diastolic pressure by multiplying a peak plethysmographic signal by a specified factor.

14. A method in accordance with claim 13, wherein the factor is between 0.75 and 0.85.

15. A method in accordance with claim 1, wherein the arterial blood pressure feature is derived from the value of an externally applied pressure and the height at which a peak plethymographic signal is obtained.

16. An improved blood pressure measurement device of the type having a plethysmographic sensor disposed on an extremity of a subject capable of sensing a plurality of plethysmographic signals at a plurality of heights of the sensor relative to the heart of the subject, and at a plurality of externally applied pressures at each height of the sensor, the improvement comprising:

a solid protrusion for externally applying a focal pressure to the extremity of the subject, the focal pressure having a value that may vary; and

a processor receiving the plurality of plethysmographic signals from the sensor, the processor determining a relationship characterizing variation of the pelthymographic signal with the plurality of heights of the sensor and the plurality of externally applied pressures, deriving an arterial blood pressure feature based on at least the relationship characterizing variation of the plethysmographic signal with the plurality of heights of the sensor and the externally applied pressures, and on an instantaneously measured plethysmographic signal and height of the sensor relative to the heart of the subject.

17. A device in accordance with claim 16, wherein the processor models the relationship of a derived arterial pressure to plethysmographic signal by fitting parameters of a specified functional relationship.

18. A device in accordance with claim 16, wherein the focal pressure is additionally varied by means of an inflatable cuff.

19. A device in accordance with claim 16, wherein the focal pressure is additionally varied by means of a band using a polymer actuator.

20. A device in accordance with claim 16, wherein measurement of a plurality of heights of the sensor is derived from at least one angular displacement of an extremity.

21. A device in accordance with claim 16, wherein the processor contains a data filter for removing spurious data points from the plethysmographic signals.

22. A device in accordance with claim 16, wherein the processor is capable of deriving a systolic pressure by multiplying a peak plethysmographic signal by a factor.

23. A device in accordance with claim 22, wherein the factor is approximately 0.5.

24. A device in accordance with claim 16, wherein the processor is capable of deriving a diastolic pressure by multiplying a peak plethysmographic signal by a factor.

25. A device in accordance with claim 24, wherein the factor is between 0.75 and 0.85.

26. A device in accordance with claim 16, wherein the processor derives the arterial blood pressure feature from the value of an externally applied pressure and the height at which a peak plethymographic signal is obtained.

27. A method for performing a circulatory measurement on an extremity of a subject, the method comprising:

measuring a plethysmographic signal of a plethysmographic sensor disposed on the extremity of the subject at a plurality of heights of the sensor, relative to the heart of the subject, and at a plurality of externally applied pressures at each height of the sensor;

determining a relationship characterizing variation of the plethysmographic signal with the plurality of heights of the sensor and the plurality of externally applied pressures; and

deriving an arterial blood pressure feature based on at least the relationship characterizing variation of the plethysmographic signal with the plurality of heights of the sensor and the plurality of externally applied pressures, and on an instantaneously measured plethysmographic signal and height of the sensor relative to the heart of the subject.

28. A method in accordance with claim 27, further comprising:

modeling the relationship of a derived arterial pressure to the plethysmographic signal by fitting parameters of a specified functional relationship.

29. A method in accordance with claim 27, further comprising:

modeling the relationship of a derived mean arterial pressure to a peak plethysmographic signal by fitting parameters of a specified functional relationship.

30. A method in accordance with claim 27, wherein the plethysmographic signal is a photoplethysmographic signal.

31. A method in accordance with claim 27, wherein external pressure is applied by means of an inflatable cuff.

32. A method in accordance with claim 27, wherein external the focal pressure is varied applied by means of a band using a polymer actuator.

33. A method in accordance with claim 27, wherein external pressure is applied by a sensor holder with a protrusion.

34. A method in accordance with claim 27, wherein measurement of a plurality of heights of the sensor is derived from at least one angular displacement of the extremity.

35. A method in accordance with claim 34, wherein the at least one angular displacement of the extremity is obtained by means of an accelerometer.

36. A method in accordance with claim 27, further comprising:

removing spurious data points from the plethysmographic signal.

37. A method in accordance with claim 27, further comprising:

removing oscillations between beats of the heart from the plethysmographic signal.

38. A method in accordance with claim 27, further comprising:

deriving a systolic pressure by multiplying a peak plethysmographic signal by a specified factor.

39. A method in accordance with claim 38, wherein the factor is approximately 0.5.

40. A method in accordance with claim 27, further comprising:

deriving a diastolic pressure by multiplying a peak plethysmographic signal by a specified factor.

41. A method in accordance with claim 40, wherein the factor is between 0.75 and 0.85.

42. A method in accordance with claim 27, wherein a mean arterial pressure is derived from a value of an externally applied pressure at which a peak plethysmographic signal amplitude is obtained and from the height at which a peak plethysmographic signal is obtained.

43. A method in accordance with claim 27, wherein the arterial blood pressure feature is derived from a value of an externally applied pressure and the height at which a peak plethymographic signal is obtained.

44. An improved blood pressure measurement device of the type having a plethysmographic sensor disposed on an extremity of a subject capable of sensing a plurality of plethysmographic signals at a plurality of heights of the sensor relative to the heart of the subject, and at a plurality of externally applied pressures at each height of the sensor, the improvement comprising:

a processor receiving the plurality of plethysmographic signals from the sensor, the processor determining a relationship characterizing variation of the plethysmographic signal with the plurality of heights of the sensor and the plurality of externally applied pressures, and deriving an arterial blood pressure feature based on at least the relationship characterizing variation of the plethysmographic signal with the plurality of heights of the sensor and the externally applied pressures, and on an instantaneously measured plethysmographic signal and height of the sensor relative to the heart of the subject.

45. A device in accordance with claim 44, wherein the processor models the relationship of a derived arterial pressure to plethysmographic signal by fitting parameters of a specified functional relationship.

46. A device in accordance with claim 44, wherein external pressure is applied by means of an inflatable cuff.

47. A device in accordance with claim 44, wherein the focal pressure is varied by means of a band using a polymer actuator.

48. A device in accordance with claim 44, wherein the external pressure is applied by a sensor holder with a protrusion.

49. A device in accordance with claim 44, wherein measurement of a plurality of heights of the sensor is derived from at least one angular displacement of an extremity.

50. A device in accordance with claim 44, wherein the processor contains a data filter for removing spurious data points from the plethysmographic signals.

51. A device in accordance with claim 44, wherein the processor is capable of deriving a systolic pressure by multiplying a peak plethysmographic signal by a factor.

52. A device in accordance with claim 51, wherein the factor is approximately 0.5.

53. A device in accordance with claim 44, wherein the processor is capable of deriving a diastolic pressure by multiplying a peak plethysmographic signal by a factor.

54. A device in accordance with claim 53, wherein the factor is between 0.75 and 0.85.

55. A device in accordance with claim 44, wherein a mean arterial pressure is derived from a value of an externally applied pressure at which a peak plethysmographic signal is obtained and from the height at which a peak plethysmographic signal is obtained.

56. A device in accordance with claim 44, wherein the processor derives the arterial blood pressure feature from a value of an externally applied pressure and the height at which a peak plethymographic signal is obtained.