Addressing recurrent atrial fibrillation

• US 7,647,107 B2
• Filed: 09/18/2006
• Issued: 01/12/2010
• Est. Priority Date: 10/31/2002
• Status: Expired due to Fees

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Holzer, Stefan, Puererfellner, Helmut, Hettrick, Douglas A., Warman, Eduardo N., Ziegler, Paul D.
• Primary Examiner(s): Layno; Carl H.
• Assistant Examiner(s): Heller; Tammie K.
• Application Number:
  US11/532,741
• Publication Number:
  US 20070038258A1
• Time in Patent Office: 1,212 Days
• Field of Search: 607/4, 607/14, 607/17, 607/25
• US Class Current: 607/25
• CPC Class Codes: A61N 1/395 for treating atrial fibrillation
• CPC Class Codes: A61N 1/3962 in combination with another heart therapy
• CPC Class Codes: A61N 1/39622 Pacing therapy

Abstract

Techniques for applying overdrive pacing to one or both atria following termination of an AF episode, to prevent a recurrent AF episode. An implantable medical device such as a pacemaker applies overdrive pacing according to overdrive pacing parameters, and sets the parameters as a function of the response of the patient to overdrive pacing. The parameters may be adjusted upward or downward, so that overdrive pacing may be applied effectively but not over-applied.

Claims

1. A method comprising:

monitoring for episodes of atrial fibrillation in an evaluation period;

computing a measure of episodes of detected atrial fibrillation in the evaluation period that are followed by detected recurrent episodes of atrial fibrillation;

comparing the measure to a threshold; and

setting an overdrive pacing parameter as a function of the comparison.

2. The method of claim 1, wherein setting the overdrive pacing parameter comprises one of increasing and decreasing the overdrive pacing rate.

3. The method of claim 1, wherein setting the overdrive pacing parameter comprises one of increasing and decreasing the overdrive pacing duration.

4. The method of claim 1, wherein the threshold is a maximum threshold, and wherein setting the overdrive pacing parameter comprises increasing the overdrive pacing rate when the ratio of detected recurrent atrial fibrillation episodes to the total detected atrial fibrillation episodes is above the maximum threshold.

5. The method of claim 4, wherein setting the overdrive pacing parameter comprises one of increasing and decreasing the overdrive pacing duration.

6. A computer-readable medium comprising instructions for causing a programmable processor to:

monitor for episodes of atrial fibrillation in an evaluation period;

compute a measure of episodes of detected atrial fibrillation in the evaluation period that are followed by detected recurrent episodes of atrial fibrillation;

compare the measure to a threshold; and

set an overdrive pacing parameter as a function of the comparison.

7. The medium of claim 6, wherein the instructions that cause the processor to set the overdrive pacing parameter comprise instructions to cause the processor to perform one of increasing and decreasing the overdrive pacing rate.

8. The medium of claim 6, wherein the instructions that cause the processor to set the overdrive pacing parameter comprise instructions to cause the processor to perform one of increasing and decreasing the overdrive pacing duration.

9. The medium of claim 6, wherein the threshold is a maximum threshold, and wherein the instructions cause the processor to set the overdrive pacing parameter by increasing the overdrive pacing rate when the ratio of detected recurrent atrial fibrillation episodes to the total detected atrial fibrillation episodes is above the maximum threshold.

10. The medium of claim 9, wherein the instructions cause the processor to set an overdrive pacing parameter by one of increasing and decreasing the overdrive pacing duration.

11. An implantable medical device comprising:

at least one electrode disposed proximate to an atrium of a heart;

a pulse generator coupled to the electrode; and

a processor to control the pulse generator to deliver overdrive pacing therapy to the atrium via the electrode according to an overdrive pacing parameter following an episode of atrial fibrillation, monitor for episodes of atrial fibrillation in an evaluation period, compute a measure of episodes of detected atrial fibrillation in the evaluation period that are followed by detected recurrent episodes of atrial fibrillation, compare the measure to a threshold and set the overdrive pacing parameter as a function of the comparison.

12. The device of claim 11, further comprising sensing circuitry to detect at least one episode of atrial fibrillation and monitor for an episode of recurrent atrial fibrillation following the detected episode of atrial fibrillation.

13. The device of claim 11, further comprising a telemetry unit to receive the threshold.

14. The device of claim 11, wherein the device operates in a plurality of pacing modes, and wherein the device selects a pacing mode as a function of a detected episode of atrial fibrillation.

15. The device of claim 11, wherein the processor is configured to set the overdrive pacing parameter by at least one of increasing and decreasing the overdrive pacing rate.

16. The device of claim 11, wherein the processor is configured to set the overdrive pacing parameter by at least one of increasing and decreasing the overdrive pacing duration.

17. The device of claim 11, wherein the threshold is a maximum threshold, and wherein the processor is configured to set the overdrive pacing parameter by increasing the overdrive pacing rate when the ratio of detected recurrent atrial fibrillation episodes to the total detected atrial fibrillation episodes is above the maximum threshold.

18. The device of claim 17, wherein the processor is configured to set the overdrive pacing parameter by at least one of increasing and decreasing the overdrive pacing duration.