Mechanochemical sensor

• US 7,650,804 B2
• Filed: 07/27/2004
• Issued: 01/26/2010
• Est. Priority Date: 07/30/2003
• Status: Expired due to Fees

• Current Assignee: Fuence Co., Ltd., Riken
• Original Assignee: Fuence Co., Ltd., Riken
• Inventors: Inoue, Kozo, Ohmori, Hitoshi, Kim, Joon-wan, Yamagata, Yutaka
• Primary Examiner(s): Caputo; Lisa M
• Assistant Examiner(s): DAVIS, OCTAVIA L
• Application Number:
  US10/566,355
• Publication Number:
  US 20060219030A1
• Time in Patent Office: 2,009 Days
• Field of Search: 738/626.34, 73/645.3
• US Class Current: 73/862.634
• CPC Class Codes: C12Q 1/6825 Nucleic acid detection involving sensors
• CPC Class Codes: G01N 5/02 by absorbing or adsorbing components of a material and determining change of weight of the adsorbent, e.g. determining moisture content absorption bulbs B01D53/00

Abstract

There is provided a mechanochemical sensor including a minute mechanical structure body having the functional membrane formed at least on one part of its surface, a supporting part for supporting the minute mechanical structure body; and a detection part for detecting the change of a mechanical property of the minute mechanical structure body. According to the invention, it is possible to provide improved adhesion between the functional membrane and the minute mechanical structure body since the functional membrane is integrally formed in advance on the minute mechanical structure body, which will contribute to the increase of detection signal, and improvement of measurement precision and sensitivity.

Claims

1. A mechanochemical sensor comprising:

a minute mechanical structure body having a supporting portion and a pair of arms connected via elastic hinges to the support portion;

a functional membrane that is connected to both arms;

a detection means for detecting the change of a mechanical property of the functional membrane, the detection means including a force detection sensor that is connected to one of the arms; and

an actuator for providing tension to the functional membrane, the actuator being connected to the other of the arms.

2. A mechanochemical sensor as described in claim 1 wherein:

the minute mechanical structure body comprises a first region having the functional membrane formed on its surface and the first region is a thin layer.

3. A mechanochemical sensor as described in claim 1 wherein the minute mechanical structure body is a plurality of minute structure bodies each comprising a different functional membrane.

4. A mechanochemical sensor as described in claim 1 wherein the functional membrane is made of a biopolymer or a synthetic polymer.

5. A mechanochemical sensor as described in claim 1 wherein the functional membrane is formed directly on a surface of the minute mechanical structure body by electro-spray deposition.

6. A mechanochemical sensor as described in claim 5 wherein:

the minute mechanical structure body comprises a zone which will not be displaced or displaced negligibly even when a mechanical property of the functional membrane is changed, and

the minute mechanical structure body has its one end immersed into a test solution such that said zone is close to the surface of the test solution.

7. A mechanochemical sensor as described in claim 6 wherein:

the detection means comprises a force-detection sensor and an actuator for providing a tension to the functional membrane.

8. A mechanochemical sensor as described in claim 6 wherein:

the minute mechanical structure body comprises a minute cantilever having a functional membrane formed thereon; and

the detection means is a sensor capable of detecting the bending deformation of the minute cantilever of minute mechanical structure body.

9. A mechanochemical sensor as described in claim 5 wherein:

the detection means comprises a force-detection sensor and an actuator for providing a tension to the functional membrane.

10. A mechanochemical sensor as described in claim 9 wherein:

the minute mechanical structure body comprises a minute cantilever having the functional membrane formed thereon; and

the detection means is a sensor capable of detecting the bending deformation of the minute cantilever of the minute mechanical structure body.

11. A mechanochemical sensor as described in claim 5 wherein:

the minute mechanical structure body comprises a minute cantilever having the functional membrane formed thereon; and

the detection means is a sensor capable of detecting the bending deformation of the minute cantilever of the minute mechanical structure body.

12. A mechanochemical sensor as described in claim 1 wherein the functional membrane is formed directly on a surface of the minute mechanical structure body by ink jet deposition.

13. A mechanochemical sensor as described in claim 12 wherein:

the detection means comprises a force-detection sensor and an actuator for providing a tension to the functional membrane.

14. A mechanochemical sensor as described in claim 13 wherein:

the minute mechanical structure body comprises a minute cantilever having the functional membrane formed thereon; and

the detection means is a sensor capable of detecting the bending deformation of the minute cantilever of the minute mechanical structure body.

15. A mechanochemical sensor as described in claim 14 wherein:

the minute mechanical structure body comprises a minute cantilever having the functional membrane formed thereon; and

the detection means is a sensor capable of detecting the bending deformation of the minute cantilever of the minute mechanical structure body.