Method and apparatus for glucose control and insulin dosing for diabetics
First Claim
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1. A run-to-run control method of deriving the optimal dosage of insulin to provide both the basal insulin requirement and the meal-related insulin dosing of an individual having diabetes, comprising:
- determining an insulin sensitivity matrix for said individual;
measuring a postprandial glucose response to at least one meal; and
estimating a preprandial dosage of insulin for a subsequent cycle'"'"'s corresponding meal based on said insulin sensitivity matrix of said individual and measured postprandial glucose response to the meal and preprandial dose of insulin for a current cycle;
wherein each element of said insulin sensitivity matrix is a function of one or more parameters affecting insulin needs of an individual pertaining to said individual;
wherein said one or more parameters is selected from the group consisting of physical stress, psychological stress, hormonal stress, activity, fitness, and weight;
wherein said insulin sensitivity matrix reflects a breadth of output responses in said individual as a function of changes in input; and
wherein dosage amount for a subsequent cycle is higher than, lower than, or the same as, dosage amount for a current cycle.
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Abstract
A computer implemented method and associated apparatus for the combined control of insulin bolus dosing and basal delivery for the goal of achieving normal glycemic response to meals, exercise, stressors, and other perturbations to blood glucose levels. A run-to-run algorithm is used to monitor blood glucose levels and adjust insulin delivery as conditions are varied.
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21 Claims
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1. A run-to-run control method of deriving the optimal dosage of insulin to provide both the basal insulin requirement and the meal-related insulin dosing of an individual having diabetes, comprising:
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determining an insulin sensitivity matrix for said individual; measuring a postprandial glucose response to at least one meal; and estimating a preprandial dosage of insulin for a subsequent cycle'"'"'s corresponding meal based on said insulin sensitivity matrix of said individual and measured postprandial glucose response to the meal and preprandial dose of insulin for a current cycle; wherein each element of said insulin sensitivity matrix is a function of one or more parameters affecting insulin needs of an individual pertaining to said individual; wherein said one or more parameters is selected from the group consisting of physical stress, psychological stress, hormonal stress, activity, fitness, and weight; wherein said insulin sensitivity matrix reflects a breadth of output responses in said individual as a function of changes in input; and wherein dosage amount for a subsequent cycle is higher than, lower than, or the same as, dosage amount for a current cycle. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification