Methods of treatment with pre-mixed, ready-to-use pharmaceutical compositions

  • US 7,659,291 B2
  • Filed: 03/19/2009
  • Issued: 02/09/2010
  • Est. Priority Date: 04/18/2006
  • Status: Active Grant
First Claim
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1. A method for treating acute elevations of blood pressure in a human subject in need thereof, said method comprising parenterally administering a composition comprising from about 0.1 to 0.4 mg/mL nicardipine or a pharmaceutically acceptable salt thereof;

  • a tonicity agent; and

    a buffer;

    wherein the composition requires no dilution before administration and has a pH from about 3.6 to about 4.7, the composition when stored in container for at least three months at room temperature exhibiting (i) less than a 10% decrease in the concentration of nicardipine or pharmaceutically acceptable salt thereof and (ii) a total impurity formation of less than about 3%.

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