Polypeptide having heparanase activity
First Claim
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1. A preparation comprising protein molecules, said preparation including heparanase (endo-β
- -D-glucuronidase) protein, said heparanase protein having heparanase catalytic activity or being cleavable so as to acquire said heparanase catalytic activity, wherein said heparanase protein comprises SEQ ID NO;
10, provided that said amino acid sequence has a phenylalanine residue instead of a tyrosine residue at position 246, and wherein said preparation is pure enough to elicit anti-heparanase antibodies.
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Abstract
A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, genetically modified cells expressing heparanase, a recombinant protein having heparanase activity and antisense oligonucleotides and constructs for modulating heparanase expression.
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2 Claims
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1. A preparation comprising protein molecules, said preparation including heparanase (endo-β
- -D-glucuronidase) protein, said heparanase protein having heparanase catalytic activity or being cleavable so as to acquire said heparanase catalytic activity, wherein said heparanase protein comprises SEQ ID NO;
10, provided that said amino acid sequence has a phenylalanine residue instead of a tyrosine residue at position 246, and wherein said preparation is pure enough to elicit anti-heparanase antibodies.
- -D-glucuronidase) protein, said heparanase protein having heparanase catalytic activity or being cleavable so as to acquire said heparanase catalytic activity, wherein said heparanase protein comprises SEQ ID NO;
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2. A purified heparanase protein comprising SEQ ID NO:
- 10, provided that said amino acid sequence has a phenylalanine residue instead of a tyrosine residue at position 246.
Specification