Methods and devices for reducing the mineral content of a region of non-intimal vascular tissue

• US 7,670,311 B2
• Filed: 11/04/2005
• Issued: 03/02/2010
• Est. Priority Date: 08/25/1999
• Status: Expired due to Term

• Current Assignee: Cardinal Health Switzerland 515 GmbH (Cardinal Health, Inc.)
• Original Assignee: Cordis Corporation (Cardinal Health, Inc.)
• Inventors: Constantz, Brent R.
• Primary Examiner(s): Mendez; Manuel A
• Application Number:
  US11/267,038
• Publication Number:
  US 20060155242A1
• Time in Patent Office: 1,579 Days
• Field of Search: 604/48, 604/500, 604/506, 604/507, 604/508, 604/509, 604/511, 604/513
• US Class Current: 604/93.01
• CPC Class Codes: A61B 17/08 Wound clamps or clips, i.e. not or only partly penetrating the tissue suture bridges A61B17/0466; Devices for bringing together the edges of a wound
• CPC Class Codes: A61B 17/11 for performing anastomosis; Buttons for anastomosis
• CPC Class Codes: A61B 2017/00778 Operations on blood vessels A61B2017/22097, A61B2017/320741 take precedence
• CPC Class Codes: A61B 2017/00893 pharmaceutically effective
• CPC Class Codes: A61B 2017/1107 for blood vessels
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092

Abstract

Methods and devices for reducing the mineral content of a region of non-intimal vascular tissue are provided. In the subject methods, an isolated local environment that includes the region to be demineralized is produced. The pH of the local environment is then reduced to a subphysiologic level, e.g. by flushing with an acidic dissolution fluid, for a period of time sufficient for the mineral content of the region to be reduced. The devices of the subject invention are characterized by comprising a means for producing an isolated local environment that includes a non-intimal region of vascular tissue. Also provided are kits for practicing the subject methods.

Claims

1. A device for use in reducing the mineral context of a region of non-initmal vascular tissue, said device comprising:

a means for producing an isolated local environment in situ comprising a region of non-intimal vascular tissue, said means including a removable isolation chamber configured for maintaining a fluid tight seal when attached to the vascular tissue; and

an inlet and an outlet for introducing and removing an acidic dissolution fluid.