MYH gene variants and use thereof
DC CAFCFirst Claim
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1. A method for genotyping an individual comprising:
- detecting the 691C→
T nucleotide variant in an MYH gene obtained from said individual.
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Abstract
Variants in MYH gene are disclosed which can result in abnormal synthesis of MYH proteins and alteration of MYH activities. The invention provides methods for detecting the newly discovered genetic variants. Use of MYH genetic variants as biomarkers in diagnosing cancer and detecting a predisposition to cancer are also disclosed herein.
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14 Claims
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1. A method for genotyping an individual comprising:
detecting the 691C→
T nucleotide variant in an MYH gene obtained from said individual.- View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method for determining an increased likelihood for developing colon cancer in an individual, comprising:
determining from a sample obtained from said individual whether said individual has the 691C→
T nucleotide variant in an MYH gene of said individual, wherein the presence of said nucleotide variant is indicative of an increased likelihood for developing colon cancer.- View Dependent Claims (9, 10, 11, 12, 13, 14)
Specification