Abuse-resistant amphetamine prodrugs

CAFC
  • US 7,674,774 B2
  • Filed: 08/29/2008
  • Issued: 03/09/2010
  • Est. Priority Date: 02/22/2002
  • Status: Active Grant
First Claim
Patent Images

1. A composition comprising from 25 to 75 mg of L-lysine-d-amphetamine or a salt thereof and having an amphetamine base amount of from 7.37 to 22.1 mg of said amphetamine, said L-lysine-d-amphetamine or a salt thereof providing at least one property selected from the group consisting of a mean AUC0-12 h (ng h/mL) from 205.4±

  • 42.5 to 611.5±

    104.5, a mean AUClast (ng h/mL) from 396.7±

    84.8 to 1237.0±

    194.0, a mean AUCinf (ng h/mL) from 415.0±

    80.1 to 1259.5±

    191.3, a mean Cmax (ng/mL) from 25.0±

    5.6 to 74.0±

    12.9, a mean Tmax (hours) from 3.1±

    0.876 to 3.9±

    1.0, and a mean T1/2 (hours) from 9.68±

    1.43 to 10.3±

    1.7 of amphetamine when orally administered to a human subject.

View all claims
    ×
    ×

    Thank you for your feedback

    ×
    ×