Polymeric hybrid precursors, polymeric hybrid precursor composite matrices, medical devices, and methods

• US 7,674,864 B2
• Filed: 12/23/2005
• Issued: 03/09/2010
• Est. Priority Date: 12/23/2005
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Zoromski, Michele L., Atanasoska, Liliana L., Warner, Robert W., Schewe, Scott R.
• Primary Examiner(s): PENG, KUO LIANG
• Application Number:
  US11/317,613
• Publication Number:
  US 20070149743A1
• Time in Patent Office: 1,537 Days
• Field of Search: 525/403, 525/55, 528/901
• US Class Current: 525/403
• CPC Class Codes: A61L 27/48 with macromolecular fillers
• CPC Class Codes: C08G 18/4854 Polyethers containing oxyalkylene groups having four carbon atoms in the alkylene group
• CPC Class Codes: C08G 18/718 containing silicon
• CPC Class Codes: C08G 2270/00 Compositions for creating interpenetrating networks
• CPC Class Codes: C08G 77/458 containing polyurethane sequences
• CPC Class Codes: C08L 77/00 Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain of polyhydrazides C08L79/06; of polyamideimides or polyamide acids C08L79/08; Compositions of derivatives of such polymers
• CPC Class Codes: C08L 83/04 Polysiloxanes
• CPC Class Codes: C08L 83/14 in which at least two but not all the silicon atoms are connected by linkages other than oxygen atoms C08L83/10 takes precedence
• CPC Class Codes: C08L 83/16 in which all the silicon atoms are connected by linkages other than oxygen atoms
• CPC Class Codes: Y10S 528/901 Room temperature curable silicon-containing polymer

Abstract

Polymeric hybrid precursors, mixtures of polymeric hybrid precursors and polymers, and polymer composite matrices prepared from the mixture of the polymeric hybrid precursors and the polymer. The mixture of the polymeric hybrid precursors and the polymer can undergo a process to form the polymer composite matrix having a cross-linked network of a silasesquioxane based polymer formed from the polymeric hybrid precursors that interpenetrates the polymer. The polymeric hybrid precursors include chemical linkage moieties that are capable of forming non-covalent bonds with portions of the polymer. The polymer composite matrices are useful as biomaterials in medical devices.

Claims

1. A polymeric hybrid precursor comprising a compound of the formula [(R₂O)₃—

Si—

R₃—

O—

CH₂—

(CHOH)—

CH₂]₂ —

N—

[(R_l)_m—

O_x]_q—

N—

[CH₂—

(CHOH)—

CH₂O—

R₃—

Si—

(OR₂)₃]₂, where x is 1;

m is 1 to 18; and

q is 1 to 200;

R₁, R₂, and R₃ are each independently an organic group.

2. The polymeric hybrid precursor of claim 1, where the compound of the formula [(R₂O)₃—

Si—

R₃O—

CH₂—

(CHOH)—

CH₂]₂—

N—

[(R_l)_m—

O_x]_q—

N —

[CH₂—

(CHOH)-CH₂—

O—

R₃—

Si—

(OR₂)₃]₂ is derived from at least one compound of the formula (Formula II) RO_f—

(C═

O)_i—

[(R_l)_m—

O_x]_q(C═

O)_n—

O_e—

R and at least one alkoxy silane containing compound of the formula (Formula III) (R₂O)₃Si(R₃—

A), where i, n, e and f are each independently 0 or 1;

x is 1;

each R is independently H, an amine, an isocyanate, or an organic group;

each R_1, R_2, and R₃ is independently an organic group, m is 1 to 18; and

q is 1to 200; and

A is independently, an isocyanate, an amine, or an epoxy compound.

3. The polymeric hybrid precursor of claim 1, where R₂ is a (C1-C8) alkyl group and each R₁ and R₃ is independently a (C1-C8) alkylene group.

4. The polymeric hybrid precursor of claim 1, where the compound of the formula [(R₂O)₃—

Si—

R₃—

O—

CH₂—

(CHOH)—

CH₂]₂—

N—

[(R₁)_m—

O_x]_q—

N—

[CH₂—

(CHOH)—

CH₂—

O—

R₃—

Si—

(OR₂)₃]₂ can melt.

5. The polymeric hybrid precursor of claim 1, where the polymeric hybrid precursor can be mixed in a polymer to form a mixture, where the polymeric hybrid precursor includes chemical linkage moieties that can non-covalently bond with portions of the polymer.

6. The polymeric hybrid precursor of claim 5, where the polymeric hybrid precursor mixed in the polymer can be shaped through a molding process selected from the group of blow molding, injection molding, extrusion, casting, coating and fiber spinning.

7. The polymeric hybrid precursor of claim 1, where the compound of the formula [(R₂O)₃—

Si—

R₃—

O—

CH₂—

(CHOH)—

CH₂]₂—

N—

[(R₁)_m—

O_x]_q—

N—

[CH₂—

(CHOH)—

CH₂—

O—

R₃—

Si—

(OR₂)₃]₂ can form a cross-linked network that interpenetrates a polymer using a sol-gel process.

8. A medical device prepared from the polymeric hybrid precursor of claim 1.