Device for extracting gas or liquid from microfluidid through-flow systems

• US 7,682,430 B2
• Filed: 08/13/2002
• Issued: 03/23/2010
• Est. Priority Date: 08/18/2001
• Status: Expired due to Fees

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Roche Diagnostics Corporation (Roche Holding AG)
• Inventors: Kraemer, Peter, Ocvirk, Gregor, Koelker, Karl-Heinz, Effenhauser, Carlo
• Primary Examiner(s): Hopkins; Robert A
• Application Number:
  US10/487,101
• Publication Number:
  US 20050000364A1
• Time in Patent Office: 2,779 Days
• Field of Search: 961/55, 961/93, 422/100
• US Class Current: 96/155
• CPC Class Codes: B01J 2219/00788 Three-dimensional assemblies, i.e. the reactor comprising a form other than a stack of plates
• CPC Class Codes: B01J 2219/00891 Feeding or evacuation
• CPC Class Codes: B01J 2219/00905 Separation
• CPC Class Codes: B01L 2200/027 for microfluidic devices
• CPC Class Codes: B01L 2200/141 Preventing contamination, tampering
• CPC Class Codes: B01L 3/502723 characterised by venting arrangements

Abstract

The invention concerns a device which is used to separate gas or liquid from microfluidic flow-through systems. The gas or liquid separation is achieved independently of the spatial orientation of the device. In addition the invention concerns a microfluidic flow-through system in which a device according to the invention enables bubble-free fluid transport.

Claims

1. A microfluidic device for separating liquid and gaseous phases in a microfluidic flow-through systems which can be operated independently of its orientation comprising:

a hollow body connected to the microfluidic flow-through system such that the liquid to be transported is conveyed through the hollow body;

wherein the hollow body comprises an inlet opening and outlet opening for feeding in and discharging the liquid;

the hollow body defining a hollow space that is sized such that liquid and gas phases in the hollow space are prevented from mixing due to capillary and adhesion forces;

wherein the inlet opening and the outlet opening are connected to a feed tube, wherein the feed tube extends into a hollow space of the hollow body; and

wherein the feed tube at the inlet opening protrudes into the interior space of the hollow body such that it prevents a direct flow from the inlet opening to the outlet opening.

2. The microfluidic device of claim 1, wherein the cross-section of the hollow body in relation to the cross-section of the inlet opening or the cross-section of the feed tube is of such a magnitude that the flow rate decreases when the interior space of the liquid flows into the interior space of the hollow body.

3. The microfluidic device of claim 1, wherein the separated phase remains in the hollow space of the body and displaces the flowing phase.

4. The microfluidic device of claim 1, wherein the hollow space of the hollow body has a high degree of symmetry.

5. The microfluidic device of claim 1, wherein the hollow space of the hollow body is spherical.

6. The microfluidic device of claim 1, wherein the feed tube for the outlet opening extends to the centre of the hollow space of the hollow body.

7. The microfluidic device of claim 1, wherein the inlet opening has no feed tube extending into the hollow space of the hollow body.

8. The microfluidic device of claim 1, wherein the outlet opening is arranged relative to the inlet opening such that an imaginary connection between the inlet opening, the outlet opening and centre of the hollow space of the hollow body forms a triangle.

9. The microfluidic device of claim 8, wherein the feed tubes are arranged on the sides of the triangle.

10. The microfluidic device of claim 1, wherein the outlet opening is next to the inlet opening.

11. The microfluidic device of claim 1, further comprising a screen that prevents a direct flow from the inlet opening to the outlet opening.

12. The microfluidic device of claim 1,further comprising a connecting system connected to the hollow body for conveying substances.

13. The microfluidic device of claim 12, wherein the connecting system comprises a first connecting piece at the inlet opening of the hollow body to pass fluid into the hollow space and a second connecting piece at the outlet opening of the hollow body to convey the fluid forwards whereby the separated gas remains in the hollow space of the hollow body.

14. The microfluidic device of claim 12, wherein the connecting system has a pump to control the flow rate of the liquid to the inlet opening of the hollow body.

15. The microfluidic device of claim 12, further comprising a liquid reservoir, wherein the liquid reservoir is connected to the connecting system.

16. The microfluidic device of claim 15, wherein the liquid reservoir is connected to the a first connecting piece at the inlet opening.

17. The microfluidic device of claim 1, further comprising a microdialysis system downstream from the hollow body, such that liquid reaching the microdialysis system is substantially free from gases.

18. The microfluidic device of claim 1, further comprising a microdialysis probe, such that the liquid passes from the outlet opening to the probe.

19. A microfluidic device for separating liquid and gaseous phases in a microfluidic flow-through system which can be operated independently of its orientation comprising:

a hollow body connected to the microfluidic flow-through system such that the liquid to be transported is conveyed through the hollow body;

wherein the hollow body comprises an inlet opening and outlet opening for feeding in and discharging the liquid;

the hollow body defining a hollow space that is sized such that liquid and gas phases in the hollow space are prevented from mixing due to capillary and adhesion forces;

wherein the inlet opening and the outlet opening are connected to a feed tube, wherein the feed tube extends into a hollow space of the hollow body;

wherein the feed tube at the inlet opening protrudes into the interior space of the hollow body such that it prevents a direct flow from the inlet opening to the outlet opening; and

a connecting system connected to the hollow body for conveying substances.

20. The microfluidic device of claim 19, wherein the connecting system comprises a first connecting piece at the inlet opening of the hollow body to pass fluid into the hollow space and a second connecting piece at the outlet opening of the hollow body to convey the fluid forwards whereby the separated gas remains in the hollow space of the hollow body.

21. The microfluidic device of claim 19, wherein the connecting system has a pump to control the flow rate of the liquid to the inlet opening of the hollow body.

22. The microfluidic device of claim 19, further comprising a liquid reservoir, wherein the liquid reservoir is connected to the connecting system.

23. The microfluidic device of claim 22, wherein the liquid reservoir is connected to the first connecting piece at the inlet opening of the hollow body.

24. The microfluidic device of claim 19, further comprising a microdialysis system downstream from the hollow body, such that liquid reaching the microdialysis system is substantially free from gases.

25. The microfluidic device of claim 19, further comprising a microdialysis probe, such that the liquid passes from the outlet opening to the probe.