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Methods for estimating analyte-related signals, microprocessors comprising programming to control performance of the methods, and analyte monitoring devices employing the methods

  • US 7,699,775 B2
  • Filed: 10/13/2004
  • Issued: 04/20/2010
  • Est. Priority Date: 06/22/2001
  • Status: Active Grant
First Claim
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1. A method of employing an analyte monitoring device to measure an analyte amount or concentration in a subject with an analyte monitoring device having first sensor A and second sensor B, said method comprising:

  • contacting the first and second sensors with a physiological fluid of a user containing analyte, in which each sensor is in contact with the physiological fluid;

    obtaining analyte-related signals from respective first and second sensors, in which each analyte-related signal is related to the amount or concentration of analyte in the subject;

    using a microprocessor, obtaining a ratio of signals from the first sensor A relative to the second sensor B for one of interpolation and/or extrapolation calculation of estimated signal values;

    providing a series of analyte-related signals obtained by the analyte monitoring device over time, andreplacing an unusable analyte-related signal with an estimated signal by either;

    (A) if one or more analyte-related signals previous to the unusable analyte-related signal and one or more analyte-related signals subsequent to the unusable analyte related signal are available, then interpolation is used to estimate the unusable, intervening analyte-related signal;

    or(B) if two or more analyte-related signals previous to the unusable analyte-related signal are available, then extrapolation is used to estimate the unusable, subsequent analyte-related signal.

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