Synthetic immunogenic but non-amyloidogenic peptides homologous to amyloid β for induction of an immune response to amyloid β and amyloid deposits

• US 7,700,107 B2
• Filed: 09/19/2008
• Issued: 04/20/2010
• Est. Priority Date: 05/22/2000
• Status: Expired due to Fees

• Current Assignee: New York University
• Original Assignee: New York University
• Inventors: Frangione, Blas, Sigurdsson, Einar M., Wisniewski, Thomas
• Primary Examiner(s): Romeo; David S
• Assistant Examiner(s): Gamett; Daniel C
• Application Number:
  US12/234,456
• Publication Number:
  US 20090081204A1
• Time in Patent Office: 578 Days
• Field of Search: None
• US Class Current: 424/184.1
• CPC Class Codes: A61K 39/00 Medicinal preparations containing antigens or antibodies materials for immunoassay G01N33/53
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 37/04 Immunostimulants
• CPC Class Codes: C07K 14/4711 Alzheimer's disease; Amyloid plaque core protein
• CPC Class Codes: C07K 16/18 against material from animals or humans
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present invention relates to synthetic immunogenic but non-amyloidogenic peptides homologous to amyloid β which can be used alone or conjugated to an immunostimulatory molecule in an immunizing composition for inducing an immune response to amyloid β peptides and amyloid deposits.

Claims

1. A method for inducing an immune response to amyloid β

peptides and amyloid deposits, comprising administering a peptide comprising the amino acid sequence

2. The method of claim 1, wherein the subject is human.

3. The method of claim 1, wherein the peptide comprises an N-terminal, C-terminal, or both N- and C-terminal, polylysine or polyaspartate sequence of 4-10 residues.

4. The method of claim 1, comprising administering a conjugate comprising the peptide and a polymer.