Inhibition of pathogens by probiotic bacteria

• US 7,713,726 B2
• Filed: 02/13/2007
• Issued: 05/11/2010
• Est. Priority Date: 11/08/1999
• Status: Expired due to Fees

• Current Assignee: Ganeden Biotech, Inc. (Kerry Group PLC)
• Original Assignee: Ganeden Biotech, Inc. (Kerry Group PLC)
• Inventors: Farmer, Sean
• Primary Examiner(s): Afremova; Vera
• Application Number:
  US11/706,642
• Publication Number:
  US 20080206214A1
• Time in Patent Office: 1,183 Days
• Field of Search: None
• US Class Current: 435/252.5
• CPC Class Codes: A61K 35/742 Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: Y10S 435/832 Bacillus

Abstract

Compositions containing a lactic acid-producing bacterial strain, e.g., Bacillus coagulans for inhibition of pathogenic bacterial infections. Spores or extracellular products produced by the bacterial strains are also useful as inhibitory agents.

Claims

1. A composition comprising an isolated Bacillus coagulans GBI-30 strain (ATCC Designation Number PTA-6086).

2. The composition of claim 1, wherein said strain produces lactic acid and has an optimal growth temperature of in the range of 25-350°

C.

3. The composition of claim 1, wherein said strain produces L(+) dextrorotatory lactic acid and produces spores resistant to temperatures of up to approximately 90°

C.

4. A food or food supplement comprising the composition of claim 1.

6. The composition of claim 1, wherein said strain produces lactic acid and has an optimal growth temperature of 30°

C.

7. The composition of claim 1, wherein said composition comprises a viable vegetative bacterial cell.

8. The composition of claim 1, wherein said composition comprises a bacterial spore.

5. A composition comprising poultry feed and an isolated Bacillus coagulans GBI-30 strain (ATCC Designation Number PTA-6086).