System and method for site specific therapy
First Claim
1. An apparatus for performing site specific tissue therapy, the apparatus comprising:
- (a) one or more semipermeable microcatheters adapted to be positioned within the tissue site, and (b) a delivery and/or recovery mechanism for employing the microcatheter(s) to control the movement of bulk fluids and/or active fluid components within or between tissue portions or adjacent tissues in a manner that achieves a therapeutic effect,wherein at least one of the one or more microcatheters consists essentially of a central guidewire positioned within the microcatheter to facilitate its placement, the microcatheter and guidewire being bound together at their distal ends.
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Accused Products
Abstract
A system, including catheter apparatus, and related method for performing site specific therapy. The catheter apparatus can include one or more semipermeable microcatheters for use in performing site specific microdialysis. The system and method are particularly suited for use in addressing cerebral edema by affecting the osmolar relationship between fluids making up the brain tissue. Also disclosed is an apparatus having a delivery/recovery mechanism in the form of a pump reservoir and one or more catheters in the form of semipermeable microcatheters, for use in delivering and/or recovering fluid to and/or from a tissue site or for performing tissue engineering outside of the body. The apparatus can be used in a method to perform site specific microtherapy, including for the treatment of avascular necrosis, compartment syndrome, cerebral edema, and to improve skin flap survival in the course of reconstructive surgery.
52 Citations
39 Claims
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1. An apparatus for performing site specific tissue therapy, the apparatus comprising:
- (a) one or more semipermeable microcatheters adapted to be positioned within the tissue site, and (b) a delivery and/or recovery mechanism for employing the microcatheter(s) to control the movement of bulk fluids and/or active fluid components within or between tissue portions or adjacent tissues in a manner that achieves a therapeutic effect,
wherein at least one of the one or more microcatheters consists essentially of a central guidewire positioned within the microcatheter to facilitate its placement, the microcatheter and guidewire being bound together at their distal ends. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
- (a) one or more semipermeable microcatheters adapted to be positioned within the tissue site, and (b) a delivery and/or recovery mechanism for employing the microcatheter(s) to control the movement of bulk fluids and/or active fluid components within or between tissue portions or adjacent tissues in a manner that achieves a therapeutic effect,
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36. An apparatus for performing site specific tissue therapy, the apparatus comprising:
- (a) one or more semipermeable microcatheters adapted to be positioned within the tissue site, and (b) a delivery and/or recovery mechanism for employing the microcatheter(s) to control the movement of bulk fluids and/or active fluid components within or between tissue portions or adjacent tissues in a manner that achieves a therapeutic effect,
wherein at least one of the one or more microcatheters consists essentially of a central guidewire to facilitate its placement, the microcatheter and guidewire being bound together at their distal ends, and wherein the microcatheter with central guidewire comprises a single lumen for the flow of fluid therein. - View Dependent Claims (37, 38, 39)
- (a) one or more semipermeable microcatheters adapted to be positioned within the tissue site, and (b) a delivery and/or recovery mechanism for employing the microcatheter(s) to control the movement of bulk fluids and/or active fluid components within or between tissue portions or adjacent tissues in a manner that achieves a therapeutic effect,
Specification