Apparatus and system for delivery of drug therapies

• US 7,722,598 B2
• Filed: 02/16/2007
• Issued: 05/25/2010
• Est. Priority Date: 04/04/2003
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Ujhelyi, Michael R., Min, Xiaoyi, Mehra, Rahul
• Primary Examiner(s): Lucchesi; Nicholas D
• Assistant Examiner(s): Stigell; Theodore J
• Application Number:
  US11/675,693
• Publication Number:
  US 20070203473A1
• Time in Patent Office: 1,194 Days
• Field of Search: 604/890.1, 604/891.1, 604 65- 67, 604/288.03
• US Class Current: 604/890.1
• CPC Class Codes: A61M 2205/0266 Shape memory materials
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/16813 by controlling the degree of opening of the flow line
• CPC Class Codes: A61N 1/0568 with drug delivery

Abstract

A medical delivery system for delivering a fluid to a desired location within a body that includes a first member having an aperture, and a second member adapted to be positioned over the first member. The fluid to be delivered is contained within a fluid storage device, formed by at least one of the first member and the second member. The medical delivery system includes means for repositioning the first member relative to the second member between a first state preventing passage of the fluid through the aperture and a second state enabling passage of the fluid outward from the fluid storage device through the aperture.

Claims

1. A medical delivery system for delivering a fluid to a desired location within a body, comprising:

a first member comprised of a shape memory alloy and having an aperture;

a second member repositionable with respect to the first member;

a first fluid storage device, formed by at least one of the first member and the second member, containing the fluid; and

a power source operatively coupled to the first member, the first member being in a first state with respect to the second member when the power source does not apply power to the shape memory alloy of the first member and the first member being in a second state with respect to the second member when the power source applies power to the shape memory alloy of the first member;

wherein in the second state, the first member elongates to expose the aperture to enable passage of the fluid outward from the first fluid storage device through the aperture.

2. The system of claim 1, further comprising a pressure sensing device communicatively coupled to the power source, the pressure sensing device adapted to sense pressure and generate a pressure feedback signal, wherein the power source delivers power to the first member in response to the pressure feedback signal.

3. The system of claim 1, wherein the second member is comprised of a shape memory alloy, and wherein the power source delivers power to the first member and the second member to reposition the first member relative to the second member to enable passage of the fluid outward from the first fluid storage device through the aperture.

4. The system of claim 1, wherein the second member includes a second aperture enabling passage of the fluid outward from the first fluid storage device through the second aperture in the second state, and wherein the first member prevents passage of the fluid through the second aperture and the second member prevents passage of fluid through the aperture of the first member when in the first state.

5. The system of claim 1, wherein the shape memory alloy includes titanium nitinol.

6. The system of claim 1, wherein the first member is adapted to be disposed within the second member.

7. The system of claim 1, further comprising:

a second fluid storage device storing the fluid; and

a fluid transfer device transferring the fluid from the second fluid storage device to the first fluid storage device, wherein the first member and the second member are in the first state during transfer of the fluid from the second fluid storage device to the first fluid storage device by the fluid transfer device.

8. A medical delivery system for delivering a fluid to a desired location within a body, comprising:

a first member comprised of a shape memory alloy and having an aperture;

a second member respositionable with respect to the first member;

a first fluid storage device, formed by at least one of the first member and the second member, containing the fluid;

a power source operatively coupled to the first member, the first member being in a first state with respect to the second member when the power source does not apply power to the shape memory alloy of the first member and the first member being in a second state with respect to the second member when the power source applies power to the shape memory alloy of the first member;

wherein in the second state, the first member elongates to expose the aperture to enable passage of the fluid outward from the first fluid storage device through the aperture; and

a pressure sensing device communicatively coupled to the power source, the pressure sensing device adapted to sense pressure and generate a pressure feedback signal, wherein the power source delivers power to the first member in response to the pressure feedback signal.

9. The system of claim 8, wherein the power source delivers power to the first member to reposition the first member relative to the second member to enable passage of the fluid outward from the first fluid storage device through the aperture.

10. The system of claim 9, wherein the first member is adapted to be disposed within the second member.

11. The system of claim 8, wherein the second member is comprised of a shape memory alloy, and wherein the power source delivers a stimulus to the first member and the second member to reposition the first member relative to the second member to enable passage of the fluid outward from the first fluid storage device through the aperture.

12. The system of claim 8, wherein the second member includes a second aperture enabling passage of the fluid outward from the first fluid storage device through the second aperture in the second state, and wherein the first member prevents passage of the fluid through the second aperture and the second member prevents passage of fluid through the aperture of the first member when in the first state.

13. The system of claim 8, wherein the shape memory alloy includes titanium nitinol.

14. The system of claim 8, wherein the pressure feedback signal corresponds to maintaining fluid pressure at the aperture at a predetermined flow rate.

15. The system of claim 8, further comprising:

a second fluid storage device storing the fluid; and

a fluid transfer device transferring the fluid from the second fluid storage device to the first fluid storage device, wherein the first member and the second member are in the first state during transfer of the fluid from the second fluid storage device to the first fluid storage device by the fluid transfer device.

16. A medical delivery system for delivering a fluid to a desired location within a body, comprising:

a first member comprised of a shape memory alloy and having an aperture;

a second member adapted to be positioned over the first member;

a first fluid storage device, formed by at least one of the first member and the second member, containing the fluid;

a power source operatively coupled a power source operatively coupled to the first member, the first member being in a first state with respect to the second member when the power source does not apply power to the shape memory alloy of the first member and the first member being in a second state with respect to the second member when the power source applies power to the shape memory alloy of the first member;

wherein in the second state, the first member elongates to expose the aperture to enable passage of the fluid outward from the first fluid storage device through the aperture;

a pressure sensing device communicatively coupled to the power source, the pressure sensing device adapted to sense pressure and generate a pressure feedback signal, the power source delivering power to the first member in response to the pressure feedback signal;

a second fluid storage device storing the fluid; and

a fluid transfer device transferring the fluid from the second fluid storage device to the first fluid storage device, wherein the first member and the second member are in the first state during transfer of the fluid from the second fluid storage device to the first fluid storage device by the fluid transfer device, wherein the pressure feedback signal corresponds to maintaining fluid pressure at the aperture at a predetermined flow rate.

17. A medical delivery system for delivering a fluid to a desired location within a body, comprising:

a first cylindrical member comprised of a shape memory alloy and formed by a first cylindrical member wall and having an aperture positioned along and extending through the first cylindrical member wall;

a second cylindrical member formed by a second cylindrical wall and having a diameter greater than the first cylindrical member, the first cylindrical member positioned within the second cylindrical member; and

a power source operatively coupled to the first cylindrical member, the first cylindrical member being in a first state with respect to the cylindrical member when the power source does not apply power to the shape memory alloy of the first cylindrical member and the first cylindrical member being in a second state with respect to the second cylindrical member when the power source applies power to the shape memory alloy of the first cylindrical member;

wherein the first cylindrical member is positioned within the second cylindrical member so that the second cylindrical member wall extends over a portion of the first cylindrical member wall including the aperture to prevent passage of the fluid through the aperture in the first state, and a second state wherein the first cylindrical member elongates within the second cylindrical member so that the second cylindrical member wall extends over a portion of the first cylindrical member wall that does not include the aperture to enable passage of the fluid through the aperture.

18. The system of claim 17, further comprising:

a fluid storage device storing the fluid; and

a fluid transfer device transferring the fluid from the fluid storage device to the first cylindrical member, wherein the first cylindrical member and the second cylindrical member are in the first state during transfer of the fluid from the fluid storage device to the first cylindrical member.

19. A medical delivery system for delivering a fluid to a desired location within a body, comprising:

a first cylindrical member comprised of a shape memory alloy and formed by a first cylindrical member wall and having an aperture positioned along and extending through the first cylindrical member wall;

a second cylindrical member formed by a second cylindrical wall and having a diameter greater than the first cylindrical member, the first cylindrical member positioned within the second cylindrical member;

a power source operatively coupled to the first cylindrical member, the first cylindrical member being in a first state with respect to the cylindrical member when the power source does not apply power to the shape memory alloy of the first cylindrical member and the first cylindrical member being in a second state with respect to the second cylindrical member when the power source applies power to the shape memory alloy of the first cylindrical member;

wherein the first cylindrical member is positioned within the second cylindrical member so that the second cylindrical member wall extends over a portion of the first cylindrical member wall including the aperture to prevent passage of the fluid through the aperture in the first state, and a second state wherein the first cylindrical member elongates within the second cylindrical member so that the second cylindrical member wall extends over a portion of the first cylindrical member wall that does not include the aperture to enable passage of the fluid through the aperture.

20. The system of claim 19, wherein the stimulus is one of an electrical stimulus, a magnetic stimulus, and a thermal stimulus.

21. The system of claim 19, wherein the first cylindrical member is adapted to be disposed within the second cylindrical member.

22. A medical delivery system for delivering a fluid to a desired location within a body, comprising:

a first cylindrical member comprised of a shape memory alloy and formed by a first cylindrical member wall and having an aperture positioned along and extending through the first cylindrical member wall;

a second cylindrical member formed by a second cylindrical wall and having a diameter greater than the first cylindrical member, the first cylindrical member positioned within the second cylindrical member;

a power source operatively coupled to the first cylindrical member, the first cylindrical member being in a first state with respect to the cylindrical member when the power source does not apply power to the shape memory alloy of the first cylindrical member and the first cylindrical member being in a second state with respect to the second cylindrical member when the power source applies power to the shape memory alloy of the first cylindrical member;

wherein the first cylindrical member is positioned within the second cylindrical member so that the second cylindrical member wall extends over a portion of the first cylindrical member wall including the aperture to prevent passage of the fluid through the aperture in the first state and a second state wherein the first cylindrical member elongates within the second cylindrical member so that the second cylindrical member wall extends over a portion of the first cylindrical member wall that does not include the aperture to enable passage of the fluid through the aperture.