Apparatus for non-invasive spectroscopic measurement of analytes, and method of using the same

• US 7,734,321 B2
• Filed: 11/27/2007
• Issued: 06/08/2010
• Est. Priority Date: 07/13/2007
• Status: Active Grant

• Current Assignee: Aspiring Holdings, LLC
• Original Assignee: ALL Protect, LLC
• Inventors: White, Steve C.
• Primary Examiner(s): Winakur; Eric F
• Assistant Examiner(s): Berhanu; Etsub D
• Application Number:
  US11/945,992
• Publication Number:
  US 20090018420A1
• Time in Patent Office: 924 Days
• Field of Search: 600/310, 600/340, 600/344
• US Class Current: 600/310
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/0062 Arrangements for scanning
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/441 Skin evaluation, e.g. for skin disorder diagnosis

Abstract

An apparatus for spectroscopic evaluation of a subject'"'"'s body fluids may be used at the interstitial region adjacent to or in between a subject'"'"'s extremities using a spectroscopic probe. The spectroscopic probe may possess one or more of the movements such as rotational, translational, and/or vertical freedom necessary for the probe to contact the subject'"'"'s tissue at a consistent angle and pressure while accommodating the different size of the subject'"'"'s extremities, and may be housed in a device optimized for attaining reproducible blood flow to the region of the subject that is measured, and for minimizing the effects of the housing pulling, stretching, pressing, compressing the subject'"'"'s skin. A pressure sensor may be used to ensure that measurements are taken at an optimal pressure. A touch sensor may be used to activate a system and/or to ensure flushness. In addition, the spectroscopic measurement may be coupled with a temperature measurement means that detects the subject'"'"'s local body temperature in or near the region being measured, or the subject'"'"'s core or mean body temperature, or the ambient temperature proximate to the probe, or any combination of those measurements. The system may also include one or more indicators to communicate information to a test subject.

Claims

1. A method for non-invasively evaluating bodily fluids of a subject, comprising:

providing a source of electromagnetic radiation to a device;

supporting a lower surface of at least one of a pair of adjacent fingers of the subject;

using the device, guiding the adjacent fingers of the subject apart from one another; and

positioning the device at an interstitial location between the fingers of the subject; and

receiving the electromagnetic radiation reflected from the subject,

wherein the interstitial location is that between the base of the subject'"'"'s fingers and in a region between the plane of the subject'"'"'s palm and the top of the subject'"'"'s knuckles, and above the web.

2. The method of claim 1 also comprising applying the device to a surface of the subject at a substantially constant pressure.

3. The method of claim 2 wherein the device is applied so as to be substantially flush with the surface of the subject.

4. The method of claim 1 wherein the interstitial location is between first and second fingers of the subject.

5. The method of claim 1 wherein the electromagnetic radiation is near infrared radiation.

6. An apparatus for non-invasively evaluating bodily fluids of a subject, comprising:

means for providing a source of electromagnetic radiation to a device;

means for supporting a lower surface of at least one of a pair of adjacent fingers or toes of the subject;

means for guiding the adjacent fingers or toes of the subject apart from one another such that the device is positioned at an interstitial location between the fingers or toes of the subject not including the web; and

means for receiving the electromagnetic radiation reflected from the subject.

7. The apparatus of claim 6 also comprising means for applying the device to a surface of the subject at a substantially constant pressure.

8. The apparatus of claim 7 also comprising means for applying the device so as to be substantially flush with the surface of the subject.

9. The apparatus of claim 6 wherein the interstitial location is between first and second fingers of the subject.

10. The apparatus of claim 6 wherein the electromagnetic radiation is near infrared radiation.

11. An apparatus for non-invasively evaluating bodily fluids of a subject, comprising:

a mounting support for a probe that defines at least one path of translational movement along a surface of the mounting support;

a probe comprising a probe head and a probe body, wherein the probe body having a proximal end and a distal end, and the probe head is pivotally attached to the probe body and adapted to move along a pivotal path relative to the mounting support; and

a biasing element that exerts substantially constant force to provide translational movement of the probe;

wherein the probe is translationally movable along the at least one path in a direction away from an initial point, and the probe is biased by the substantially constant force exerted by the biasing element toward the initial point.

12. The apparatus of claim 11 wherein the probe is also movable up and down along a second path that is substantially orthogonal to the at least one path.

13. The apparatus of claim 11 wherein the biasing element is a coil spring.

14. An apparatus for non-invasively evaluating bodily fluids of a subject, comprising:

a base adapted to support a lower surface of at least one of a pair of adjacent fingers or toes of the subject;

a probe movably positioned above the base;

a biasing element exerting a substantially constant force on the probe toward an interstitial location not including the web between the adjacent fingers or toes of the subject while the apparatus is in use; and

a guide member located above the base and adapted to guide the adjacent fingers or toes of the subject apart from one another and position the subject'"'"'s interstitial location not including the web in front of the probe while the apparatus is in use.

15. The apparatus of claim 14 also comprising a biometric verification device located at the base and adapted to provide biometric verification of the subject from the lower surface of the at least one of a pair of adjacent fingers or toes of the subject.

16. The apparatus of claim 14 wherein the base is adapted to support the lower surface of both of a pair of adjacent fingers or toes of the subject.

17. The apparatus of claim 14 wherein the probe is movable both in a direction along the base relative to the interstitial location and pivotally relative to the base.

18. A probe for non-invasively evaluating bodily fluids of a subject, comprising:

a base adapted to support a lower surface of at least one of a pair of adjacent fingers or toes of the subject;

a source of electromagnetic radiation;

a probe head;

at least one fiberoptic for conveying electromagnetic radiation from the source to the probe head;

a detector;

at least a second fiberoptic for conveying electromagnetic radiation reflected from the subject to the detector; and

a guide member located above the base and adapted to guide the adjacent fingers or toes of the subject apart from one another,

wherein the probe head is adapted to be received at an interstitial location not including the web between the adjacent fingers or toes of the subject.

19. The probe of claim 18 wherein the probe is biased toward the interstitial location by a substantially constant force.

20. The probe of claim 18 wherein the probe head is pivotable so as to be able to pivot to be substantially flush with a surface of the subject.

21. The probe of claim 18 wherein the probe head is adjustable up and down relative to the interstitial location.

22. The probe of claim 18 wherein the source of electromagnetic radiation generates near infrared radiation.