Apparatus and method for monitoring pressure related changes in the extra-thoracic arterial circulatory system

• US 7,740,591 B1
• Filed: 11/29/2004
• Issued: 06/22/2010
• Est. Priority Date: 12/01/2003
• Status: Active Grant

• Current Assignee: Philips RS North America LLC (Koninklijke Philips N.V.)
• Original Assignee: RIC INVESTMENTS LLC (Respironics Incorporated)
• Inventors: Wilczek, Donald S., Scull, James A., Ayers, Eric, Hete, Bernie F., Sanders, Mark H., Starr, Eric W.
• Primary Examiner(s): Mallari; Patricia C
• Assistant Examiner(s): Toth; Karen E
• Application Number:
  US10/999,186
• Time in Patent Office: 2,031 Days
• Field of Search: 600529-543
• US Class Current: 600/534
• CPC Class Codes: A61B 5/0082 adapted for particular medical purposes
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/02427 Details of sensor
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/087 Measuring breath flow
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/725 using specific filters therefor, e.g. Kalman or adaptive filters A61B5/316 take precedence
• CPC Class Codes: A61B 5/7257 using Fourier transforms

Abstract

A method and apparatus for monitoring changes in the intra-thoracic pressure of a patient due to the patient'"'"'s respiratory activity or volumetric changes in the extra-thoracic arterial circulatory system due to cardiac function based on the changes in pressure in the patient'"'"'s extra-thoracic arterial circulatory system as measured by a plethysmography sensor, such as an photoplethysmograph. A frequency spectrum is generated for the plethysmograph signal and the frequencies of interest is isolated from the frequency spectrum by setting appropriate cutoff frequencies for the frequency spectrum. This isolated frequency is used to filter the plethysmograph signal to provide a signal indicative of the patient'"'"'s respiratory activity or cardiac function. For corrections for breathing frequency roll-off and deviations of the I:E ratio from 1:1.

Claims

1. A pulmonary monitoring system comprising:

sensing means for detecting a physiological characteristic of a patient associated with pressure changes in such a patient'"'"'s extra-thoracic arterial circulation and for outputting a first signal indicative of such pressure changes wherein the sensing means comprises a photoemitter adapted to direct light through a portion of the patient, and a photodetector adapted to receive light after having been directed through such a patient, and wherein the photoemitter emits light at a wavelength that is relatively insensitive to an oxygen saturation level of such a patient while relatively sensitive to changes in path length between the photoemitter and photodetector; and

processing means for producing a pulmonary pressure signal as a measure of such a patient'"'"'s intra-thoracic pressure due to respiration by isolating breath related pressure variations in the first signal.

2. The system according to claim 1, further comprising outputting means for providing the pulmonary pressure signal in a human perceivable format.

3. The system according to claim 1, further comprising photoemitter controlling means for controlling an intensity of light emitted by the photoemitter so as to compensate for non-breath related variations in the first signal.

4. The system according to claim 1, wherein the sensing means further includes at least one of an invasive blood pressure sensor adapted to be disposed within a patient'"'"'s extra-thoracic arterial circulation or a non-invasive pressure sensor adapted to monitor pressure fluctuations of a patient'"'"'s extra-thoracic arterial circulation.

16. The system according to claim 1, further comprising a first flow sensor adapted to quantitatively measure a flow of gas inhaled by a patient, exhaled by a patient, or both inhaled and exhaled by a patient.

17. The system according to claim 16, wherein the processing means also determines at least one of the following physiological characteristics of a patient based on the output of the first flow sensor:

(a) inspiratory tidal volume;

(b) expiratory tidal volume;

(c) inspiratory peak flow;

(d) expiratory peak flow;

(e) minute ventilation;

(e) respiratory rate;

(f) inspiratory/expiratory ratio;

(g) rapid shallow breathing index; and

(h) slope of a flow waveform during inhalation.

18. The system according to claim 16, further comprising means for delivering a supplemental flow of a supplemental gas to such a patient.

19. The system according to claim 18, further comprising a second flow sensor adapted to quantitatively measure a flow of the supplemental gas delivered to such a patient.

20. The system according to claim 19, wherein the processing means also determines the fractional concentration of supplemental gas inhaled by such a patient based on the output of the first flow sensor and the second flow sensor.

21. The system according to claim 20, wherein the sensing means forms a pulse oximeter adapted to measure a pulse oximetry arterial oxygen saturation SpO₂ of such a patient, wherein the supplemental gas is oxygen so that the processor determines a fractional concentration of oxygen inhaled by such a patient (FIO₂) based on the output of the first flow sensor and the second flow sensor, and wherein the processor determines an estimated shunt of such a patient based on the measured SpO₂ and FIO₂.

22. The system according to claim 21, further comprising a display, and wherein the processing means is programmed to cause a nomogram to be presented on the display illustrating a relationship between the measured SpO₂, the calculated FIO₂, and the estimated shunt.

23. The system according to claim 16, further comprising a pressure sensor adapted to measure a pressure at an airway of such a patient, wherein the processing means also determines at least one of the following based on an output of the pressure sensor or the output of the pressure sensor and the first flow sensor:

(a) peak inspiratory pressure;

(b) positive end expiratory pressure; and

(c) dynamic airway compliance.

24. The system according to claim 1, wherein the sensing means forms a pulse oximeter adapted to measure a pulse oximetry arterial oxygen saturation SpO₂ of such a patient, wherein the processing means also determines a pulse rate of such a patient based on the output of the pulse oximeter.

5. A pulmonary monitoring system comprising:

sensing means for detecting a physiological characteristic of a patient associated with pressure changes in such a patient'"'"'s extra-thoracic arterial circulation and for outputting a first signal indicative of such pressure changes; and

processing means for producing a pulmonary pressure signal as a measure of such a patient'"'"'s intra-thoracic pressure due to respiration by isolating breath related pressure variations in the first signal, and wherein the processing means comprises;

frequency analyzing means for determining frequency components of the first signal;

respiratory rate frequency component identifying means for identifying a respiratory rate frequency component (f_RR) from the frequency components of the first signal; and

dynamic filtering means for filtering the first signal based on the respiratory rate frequency component f_RR so as to isolate the respiratory rate frequency component f_RR from the first signal to produce the pulmonary pressure signal.

6. The system according to claim 5, wherein the frequency analyzing means is a means for performing a Fourier transform that generates the frequency components of the first signal.

7. The system according to claim 5, wherein the processing means further comprises offset removing means for removing any offset in the frequency components of the first signal.

8. The system according to claim 5, further comprising respiratory rate monitoring means for determining a respiratory rate of such a patient, and wherein the respiratory rate frequency component identifying means selects the respiratory rate frequency component f_RR from the frequency components of the first signal based on the output of the respiratory rate monitoring means.

9. The system according to claim 8, wherein the respiratory rate monitoring means is a flow sensor adapted to detect a flow of gas to or from such a patient.

10. A pulmonary monitoring system comprising:

sensing means for detecting a physiological characteristic of a patient associated with pressure changes in such a patient'"'"'s extra-thoracic arterial circulation and for outputting a first signal indicative of such pressure changes; and

processing means for producing a pulmonary pressure signal as a measure of such a patient'"'"'s intra-thoracic pressure due to respiration by isolating breath related pressure variations in the first signal, and wherein the processing means comprises;

frequency analyzing means for determining frequency components of the first signal;

heart rate frequency component identifying means for identifying a heart rate frequency component f_HR from the frequency components of the first signal; and

dynamic filtering means for filtering the physiologic signal based on the heart rate frequency component f_HR so as to remove the heart rate frequency component f_HR from the physiologic signal, thereby isolating a respiratory rate frequency component f_RR of the first signal to produce the pulmonary pressure signal.

11. The system according to claim 10, further comprising heart rate monitoring means for determining a heart rate of such a patient, and wherein the heart rate frequency component identifying means selects the heart rate frequency component f_HR from the frequency components of the first signal based on the output of the heart monitoring means.

12. The system according to claim 11, wherein the heart rate monitoring means comprises a pulse oximeter.

13. A pulmonary monitoring system comprising:

sensing means for detecting a physiological characteristic of a patient associated with pressure changes in such a patient'"'"'s extra-thoracic arterial circulation and for outputting a first signal indicative of such pressure changes; and

processing means for producing a pulmonary pressure signal as a measure of such a patient'"'"'s intra-thoracic pressure due to respiration by isolating breath related pressure variations in the first signal, and wherein the processing means comprises;

frequency analyzing means for determining frequency components of the first signal, including a respiratory rate frequency component f_RR and a heart rate frequency component f_HR;

respiratory rate frequency component f_RR identifying means for identifying the respiratory rate frequency component f_RR from the frequency components of the first signal;

heart rate frequency component f_HR identifying means for identifying the heart rate frequency component f_HR from the frequency components of the first signal; and

dynamic filtering means for filtering the first signal based on the respiratory rate frequency component f_RR and the heart rate frequency component f_HR so as to isolate the respiratory rate frequency component f_RR from the first signal to produce the pulmonary pressure signal.

14. The system according to claim 13, wherein the dynamic filtering means (1) sets a cutoff frequency (f_cutoff) as f_RR+f_smear responsive to the respiratory rate frequency component f_RR being less than the heart rate frequency component f_HR, (2) sets the cutoff frequency (f_cutoff) as f_RR−

f_smear responsive to the respiratory rate frequency component f_RR being greater than the heart rate frequency component f_HR, where f_smear is a predetermined threshold frequency, and (3) low pass filters the first signal at the cutoff frequency f_cutoff.

15. The system according to claim 14, further comprising:

respiratory rate monitoring means for determining a respiratory rate of such a patient, and wherein the respiratory rate frequency component identifying means selects the respiratory rate frequency component f_RR from the frequency components of the first signal based on the output of the respiratory rate monitoring means; and

heart rate monitoring means for determining a heart rate of such a patient, and wherein the heart rate frequency component identifying means selects the heart rate frequency component f_HR from the frequency components of the first signal based on the output of the heart monitoring means.

25. A pulmonary monitoring method comprising:

(a) providing a pulmonary monitoring system including a light emitter and light receiver;

(b) using the pulmonary monitoring system to (a) detect a physiological characteristic of a patient associated with pressure changes in such a patient'"'"'s extra-thoracic arterial circulation and (b) output a first signal indicative of such pressure changes, wherein detecting a physiological characteristic of a patient comprises;

(1) passing light through a portion of the patient using the light emitter, and

(2) receiving light using the light receiver after having been transmitted through such a patient, wherein the light has a wavelength that is relatively insensitive to an oxygen saturation level of such a patient while relatively sensitive to changes in path length between a photoemitter and photoreceiver;

(c) producing, using a controller, a pulmonary pressure signal as a measure of such a patient'"'"'s intra-thoracic pressure due to respiration by isolating breath related pressure variations in the first signal; and

(d) outputting the pulmonary pressure signal in a human perceivable format.

26. The method according to claim 25, further comprising controlling an intensity of light emitted by the photoemitter so as to compensate for non-breath related variations in the first signal.

28. The method according to claim 25, wherein detecting a physiological characteristic of a patient includes providing a non-invasive pressure sensor adapted to monitor pressure fluctuations of a patient'"'"'s extra-thoracic arterial circulation.

40. The method according to claim 25, further comprising quantitatively measuring a flow of gas inhaled by a patient, exhaled by a patient, or both inhaled and exhaled by a patient.

41. The method according to claim 40, further comprising determining at least one of the following physiological characteristics of a patient based on the measured flow:

(a) inspiratory tidal volume;

(b) expiratory tidal volume;

(c) inspiratory peak flow;

(d) expiratory peak flow;

(e) minute ventilation;

(e) respiratory rate;

(f) inspiratory/expiratory ratio;

(g) rapid shallow breathing index; and

(h) slope of a flow waveform during inhalation.

42. The method according to claim 40, further comprising delivering a supplemental flow of a supplemental gas to such a patient.

43. The method according to claim 42, further comprising quantitatively measuring a flow of the supplemental gas delivered to such a patient.

44. The method according to claim 43, further comprising determining a fractional concentration of supplemental gas inhaled by such a patient based on the output of the first flow sensor and the second flow sensor.

45. The method according to claim 43, further comprising measuring a pulse oximetry arterial oxygen saturation SpO₂ of such a patient, determining a fractional concentration of oxygen inhaled by such a patient (FIO₂) based on the output of the first flow sensor and the second flow sensor, and determining an estimated shunt of such a patient based on the measured SpO₂ and FIO₂.

46. The method according to claim 45, further comprising displaying a nomogram illustrating a relationship between the measured SpO₂, the calculated FIO₂, and the estimated shunt.

47. The method according to claim 40, further comprising measuring a pressure of gas at an airway of such a patient, and determining at least one of the following based on an output of the pressure sensor or the output of the pressure sensor and the first flow sensor:

(a) peak inspiratory pressure;

(b) positive end expiratory pressure; and

(c) dynamic airway compliance.

48. The method according to claim 25, further comprising a pulse oximeter adapted to measure a pulse oximetry arterial oxygen saturation SpO₂ of such a patient, wherein the processing means also determines a pulse rate of such a patient based on the output of the pulse oximeter.

27. A pulmonary monitoring method comprising:

detecting a physiological characteristic of a patient associated with pressure changes in such a patient'"'"'s extra-thoracic arterial circulation and for outputting a first signal indicative of such pressure changes, and wherein detecting a physiological characteristic of a patient includes providing an invasive blood pressure sensor within a patient'"'"'s extra-thoracic arterial circulation; and

producing, using a controller, a pulmonary pressure signal as a measure of such a patient'"'"'s intra- thoracic pressure due to respiration by isolating breath related pressure variations in the first signal.

29. A pulmonary monitoring method comprising:

providing a pulmonary monitoring system including (a) a sensing system adapted to detect a physiological characteristic of a patient associated with pressure changes in such a patient'"'"'s extra-thoracic arterial circulation, and (b) a controller;

detecting such a physiological characteristic using the sensing system and outputting a first signal indicative of such pressure changes to the controller; and

using the controller to produce a pulmonary pressure signal as a measure of such a patient'"'"'s intra-thoracic pressure due to respiration by isolating breath related pressure variations in the first signal, and wherein producing the pulmonary pressure signal comprises;

determining frequency components of the first signal;

identifying a respiratory rate frequency component (f_RR) from the frequency components of the first signal; and

filtering the first signal based on the respiratory rate frequency component f_RR so as to isolate the respiratory rate frequency component f_RR from the first signal to produce the pulmonary pressure signal.

30. The method according to claim 29, wherein determining frequency components of the first signal includes analyzing the first signal with a Fourier transform that generates the frequency components of the first signal.

31. The method according to claim 29, wherein producing a pulmonary pressure signal further comprises removing any offset in the frequency components of the first signal.

32. The method according to claim 29, further comprising determining a respiratory rate of such a patient via a respiratory rate monitor, and wherein identifying the respiratory rate frequency component f_RR from the frequency components of the first signal is accomplished based on the output of the respiratory rate monitor.

33. The method according to claim 32, wherein the respiratory rate monitor is a flow sensor adapted to detect a flow of gas to or from such a patient.

34. A pulmonary monitoring method comprising:

providing a pulmonary monitoring system including (a) a sensing system adapted to detect a physiological characteristic of a patient associated with pressure changes in such a patient'"'"'s extra-thoracic arterial circulation, and (b) a controller;

detecting such a physiological characteristic using the sensing system and outputting a first signal indicative of such pressure changes to the controller; and

using the controller to produce a pulmonary pressure signal as a measure of such a patient'"'"'s intra-thoracic pressure due to respiration by isolating breath related pressure variations in the first signal, and wherein producing the pulmonary pressure signal comprises;

determining frequency components of the first signal;

identifying a heart rate frequency component f_HR from the frequency components of the first signal; and

filtering the physiologic signal based on the heart rate frequency component f_HR so as to remove the heart rate frequency component f_HR from the physiologic signal, thereby isolating a respiratory rate frequency component f_RR of the first signal to produce the pulmonary pressure signal.

35. The method according to claim 34, further comprising determining a heart rate of such a patient via a heart rate monitor, and wherein identifying the heart rate frequency component f_HR from the frequency components of the first signal is accomplished based on the output of the heart rate monitor.

36. The method according to claim 35, wherein determining a heart rate of such a patient is accomplished using a pulse oximeter.

37. A pulmonary monitoring method comprising:

providing a pulmonary monitoring system including (a) a sensing system adapted to detect a physiological characteristic of a patient associated with pressure chances in such a patient'"'"'s extra-thoracic arterial circulation, and (b) a controller;

detecting such a physiological characteristic using the sensing system and outputting a first signal indicative of such pressure changes to the controller; and

using the controller to produce a pulmonary pressure signal as a measure of such a patient'"'"'s intra-thoracic pressure due to respiration by isolating breath related pressure variations in the first signal, and wherein producing a pulmonary pressure signal comprises;

determining frequency components of the first signal, including a respiratory rate frequency component f_RR and a heart rate frequency component f_HR;

identifying a respiratory rate frequency component f_RR from the frequency components of the first signal;

identifying a heart rate frequency component f_HR from the frequency components of the first signal; and

filtering the first signal based on the respiratory rate frequency component f_RR and the heart rate frequency component f_HR so as to isolate the respiratory rate frequency component f_RR from the first signal to produce the pulmonary pressure signal.

38. The method according to claim 37, wherein filtering the first signal includes:

(1) setting a cutoff frequency (f_cutoff) as f_RR+f_smear responsive to the respiratory rate frequency component f_RR being less than the heart rate frequency component f_HR,

(2) setting the cutoff frequency (f_cutoff) as f_RR−

f_smear responsive to the respiratory rate frequency component f_RR being greater than the heart rate frequency component f_HR, where f_smear is a predetermined threshold frequency, and

(3) low pass filtering the first signal at the cutoff frequency f_cutoff.

39. The method according to claim 37, further comprising:

determining a respiratory rate of such a patient via a respiratory rate monitor, and wherein identifying the respiratory rate frequency component f_RR from the frequency components of the first signal is accomplished based on the output of the respiratory rate monitor; and

determining a heart rate of such a patient via a heart rate monitor, and wherein identifying the heart rate frequency component f_HR from the frequency components of the first signal is accomplished based on the output of the heart rate monitor.