Method and device for preventing alterations in circadian rhythm

• US 7,748,845 B2
• Filed: 08/02/2007
• Issued: 07/06/2010
• Est. Priority Date: 08/28/2002
• Status: Active Grant

• Current Assignee: Circadianeye LLC
• Original Assignee: Melcort Inc.
• Inventors: Casper, Robert, Spilkin, Jonathan, Rahman, Shadab, Solo, Peter, Wardrop, Jennifer
• Primary Examiner(s): Sugarman; Scott J
• Assistant Examiner(s): PINKNEY, DAWAYNE
• Application Number:
  US11/833,072
• Publication Number:
  US 20080065177A1
• Time in Patent Office: 1,069 Days
• Field of Search: 351/163
• US Class Current: 351/163
• CPC Class Codes: A61N 2005/0648 the light being directed to the eyes
• CPC Class Codes: A61N 5/0618 Psychological treatment

Abstract

A method of maintaining circadian rhythm of a subject comprising selectively substantially blocking retinal exposure of the subject to light having a wavelength shorter than a specified wavelength during the night, and an apparatus for carrying out the claimed method comprising an optical filter that selectively at least substantially blocks light having a wavelength shorter than the specified wavelength.

Claims

1. A method of maintaining the circadian rhythm of a subject exposed to light at night comprising selectively substantially blocking retinal exposure of the subject to light of wavelengths less than about 490 nm during the night, wherein selectively substantially blocking comprises transmitting less than 40 percent of the blocked wavelengths of light, while allowing transmission of more than 40 percent of non-blocked wavelengths of light and wherein the method inhibits melatonin suppression by light at night.

2. The method of claim 1, wherein the method of maintaining the circadian rhythm comprises normalizing levels of melatonin and at least one glucocorticoid in the subject.

3. The method of claim 2, comprising normalizing the levels of melatonin and cortisol in the subject.

4. The method of claim 1, wherein the subject is awake and in an artificially lighted environment.

5. The method of claim 4, wherein the subject has Delayed Sleep Phase Syndrome.

6. The method of claim 5, wherein the subject is an adolescent.

7. The method of claim 4, wherein the method is practised throughout the night.

8. The method of claim 4, wherein the subject is a female.

9. The method of claim 4, wherein the subject is pregnant.

10. The method of claim 4, wherein substantial blocking of wavelengths of light is by means of an optical filter.

11. The method of claim 10, wherein the optical filter is incorporated into eyewear.

12. The method of claim 10, wherein the optical filter is incorporated into a light cover.

13. The method of claim 10, wherein the optical filter is incorporated into a coating for a light source.

14. The method of claim 10, wherein the optical filter is incorporated into a light source.

15. The method of claim 4, wherein the light source excludes the blocked wavelengths of light.

16. The method of claim 1, wherein selectively substantially blocking comprises transmitting less than 40 percent, less than 30 percent, less than 20 percent or less than 10 percent of the blocked wavelengths of light, while allowing transmission of more than 50 percent, 60 percent, 70 percent, 80 percent, 90 percent or 100 percent of non-blocked wavelengths of light.

17. A method of maintaining the circadian rhythm of a subject exposed to light at night comprising selectively substantially blocking retinal exposure of the subject to light of wavelengths less than about 480 nm during the night, wherein selectively substantially blocking comprises transmitting less than 40 percent of the blocked wavelengths of light, while allowing transmission of more than 40 percent of non-blocked wavelengths of light and wherein the method inhibits melatonin suppression by light at night.

18. The method of claim 17, wherein the method of maintaining the circadian rhythm comprises normalizing levels of melatonin and at least one glucocorticoid in the subject.

19. The method of claim 18, comprising normalizing the levels of melatonin and cortisol in the subject.

20. The method of claim 17, wherein the subject is awake and in an artificially lighted environment.

21. The method of claim 20, wherein the subject has Delayed Sleep Phase Syndrome.

22. The method of claim 21, wherein the subject is an adolescent.

23. The method of claim 20, wherein the method is practised throughout the night.

24. The method of claim 20, wherein the subject is a female.

25. The method of claim 20, wherein the subject is pregnant.

26. The method of claim 20, wherein substantial blocking of wavelengths of light is by means of an optical filter.

27. The method of claim 26, wherein the optical filter is incorporated into eyewear.

28. The method of claim 26, wherein the optical filter is incorporated into a light cover.

29. The method of claim 26, wherein the optical filter is incorporated into a coating for a light source.

30. The method of claim 26, wherein the optical filter is incorporated into a light source.

31. The method of claim 20, wherein the light source excludes the blocked wavelengths of light.

32. The method of claim 17, wherein selectively substantially blocking comprises transmitting less than 40 percent, less than 30 percent, less than 20 percent or less than 10 percent of the blocked wavelengths of light, while allowing transmission of more than 50 percent, more than 60 percent, more than 70 percent, more than 80 percent, more than 90 percent or 100 percent of non-blocked wavelengths of light.

33. A method of maintaining the circadian rhythm of a subject exposed to light at night comprising selectively substantially blocking retinal exposure of the subject to light of wavelengths less than about 470 nm during the night, wherein selectively substantially blocking comprises transmitting less than 40 percent of the blocked wavelengths of light, while allowing transmission of more than 40 percent of non-blocked wavelengths of light and wherein the method inhibits melatonin suppression by light at night.

34. The method of claim 33, wherein the method of maintaining the circadian rhythm comprises normalizing levels of melatonin and at least one glucocorticoid in the subject.

35. The method of claim 34, comprising normalizing the levels of melatonin and cortisol in the subject.

36. The method of claim 33, wherein the subject is awake and in an artificially lighted environment.

37. The method of claim 36, wherein the subject has Delayed Sleep Phase Syndrome.

38. The method of claim 37, wherein the subject is an adolescent.

39. The method of claim 36, wherein the method is practised throughout the night.

40. The method of claim 36, wherein the subject is a female.

41. The method of claim 36, wherein the subject is pregnant.

42. The method of claim 36, wherein substantial blocking of wavelengths of light is by means of an optical filter.

43. The method of claim 42, wherein the optical filter is incorporated into eyewear.

44. The method of claim 42, wherein the optical filter is incorporated into a light cover.

45. The method of claim 42, wherein the optical filter is incorporated into a coating for a light source.

46. The method of claim 42, wherein the optical filter is incorporated into a light source.

47. The method of claim 36, wherein the light source excludes the blocked wavelengths of light.

48. The method of claim 33, wherein selectively substantially blocking comprises transmitting less than 40 percent, less than 30 percent, less than 20 percent or less than 10 percent of the blocked wavelengths of light, while allowing transmission of more than 50 percent, more than 60 percent, more than 70 percent, more than 80 percent, more than 90 percent or 100 percent of non-blocked wavelengths of light.

49. A method of maintaining the circadian rhythm of a subject exposed to light at night comprising selectively substantially blocking retinal exposure of the subject to light of wavelengths less than about 460 nm during the night, wherein selectively substantially blocking comprises transmitting less than 40 percent of the blocked wavelengths of light, while allowing transmission of more than 40 percent of non-blocked wavelengths of light and wherein the method inhibits melatonin suppression by light at night.

50. The method of claim 49, wherein the method of maintaining the circadian rhythm comprises normalizing levels of melatonin and at least one glucocorticoid in the subject.

51. The method of claim 50, comprising normalizing the levels of melatonin and cortisol in the subject.

52. The method of claim 49, wherein the subject is awake and in an artificially lighted environment.

53. The method of claim 52, wherein the subject has Delayed Sleep Phase Syndrome.

54. The method of claim 53, wherein the subject is an adolescent.

55. The method of claim 52, wherein the method is practised throughout the night.

56. The method of claim 52, wherein the subject is a female.

57. The method of claim 52, wherein the subject is pregnant.

58. The method of claim 52, wherein substantial blocking of wavelengths of light is by means of an optical filter.

59. The method of claim 58, wherein the optical filter is incorporated into eyewear.

60. The method of claim 58, wherein the optical filter is incorporated into a light cover.

61. The method of claim 58, wherein the optical filter is incorporated into a coating for a light source.

62. The method of claim 58, wherein the optical filter is incorporated into a light source.

63. The method of claim 52, wherein the light source excludes the blocked wavelengths of light.

64. The method of claim 49, wherein selectively substantially blocking comprises transmitting less than 40 percent, less than 30 percent, less than 20 percent or less than 10 percent of the blocked wavelengths of light, while allowing transmission of more than 50 percent, more than 60 percent, more than 70 percent, more than 80 percent, more than 90 percent or 100 percent of non-blocked wavelengths of light.

65. A method of normalizing levels of melatonin and at least one glucocorticoid in a subject exposed to light at night comprising selectively substantially blocking retinal exposure of the subject to light of wavelengths selected from the group consisting of between about 420 nm and about 490 nm;

between about 430 nm and about 490 nm;

between about 440 nm and about 490 nm;

between about 420 nm and about 480 nm;

between about 430 nm and about 480 nm;

between about 440 nm and about 480 nm;

between about 420 mm and about 470 nm;

between about 430 nm and about 470 mm;

between about 440 mm and about 470 mm;

between about 420 mm and about 460 mm;

between about 430 nm and about 460 nm; and

between about 440 nm and about 460 mm;

during the night, wherein selectively substantially blocking comprises transmitting less than 40 percent of the blocked wavelengths of light, while allowing transmission of more than 40 percent of non-blocked wavelengths of light and wherein the method inhibits melatonin suppression by light at night.

66. The method of claim 65, comprising normalizing the levels of melatonin and cortisol in the subject.

67. The method of claim 65, wherein selectively substantially blocking comprises transmitting less than 40 percent, less than 30 percent, less than 20 percent or less than 10 percent of the blocked wavelengths of light, while allowing transmission of more than 50 percent, more than 60 percent, more than 70 percent more than 80 percent, more than 90 percent or 100 percent of non-blocked wavelengths of light.

68. A device for maintaining the circadian rhythm of a subject exposed to light at night comprising an optical filter that selectively substantially blocks light of wavelengths Less than about 490 nm, wherein selectively substantially blocking comprises transmitting less than 40 percent of the blocked wavelengths of light, while allowing transmission of more than 40 percent of non-blocked wavelengths of light and wherein the device inhibits melatonin suppression by light at night.

69. The device of claim 68, wherein selectively substantially blocking comprises transmitting Less than 40 percent, less than 30 percent, less than 20 percent or less than 10 percent of the blocked wavelengths of light, while allowing transmission of more than 50 percent, more than 60 percent, more than 70 percent, more than 80 percent, more than 90 percent or 100 percent of non-blocked wavelengths of light.

70. A device for maintaining the circadian rhythm of a subject exposed to light at night comprising an optical filter that selectively substantially blocks light of wavelengths selected from the group consisting of between about 420 nm and about 490 nm;

between about 430 nm and about 490 nm;

between about 440 nm and about 490 nm;

between about 420 nm and about 480 nm;

between about 430 nm and about 480 nm;

between about 440 nm and about 480 nm;

between about 420 nm and about 470 nm;

between about 430 nm and about 470 nm;

between about 440 nm and about 470 nm;

between about 420 nm and about 460 nm;

between about 430 nm and about 460 nm; and

between about 440 nm and about 460 nm, wherein selectively substantially blocking comprises transmitting less than 40 percent of the blocked wavelengths of light, while allowing transmission of more than 40 percent of non-blocked wavelengths of light and wherein the device inhibits melatonin suppression by light at night.

71. The device of claim 70, wherein selectively substantially blocking comprises transmitting less than 40 percent, less than 30 percent, less than 20 percent or less than 10 percent of the blocked wavelengths of light, while allowing transmission of more than 50 percent, more than 60 percent, more than 70 percent, more than 80 percent, more than 90 percent or 100 percent of non-blocked wavelengths of light.