Once daily formulations of tetracyclines

CAFC
  • US 7,749,532 B2
  • Filed: 04/07/2004
  • Issued: 07/06/2010
  • Est. Priority Date: 04/07/2003
  • Status: Active Grant
First Claim
Patent Images

1. An oral pharmaceutical composition of doxycycline, which at a once-daily dosage will give steady state blood levels of doxycycline of a minimum of 0.1 μ

  • g/ml and a maximum of 1.0 μ

    g/ml, the composition consisting of (i) an immediate release (IR) portion comprising a drug, wherein the drug consists of about 30 mg doxycycline;

    (ii) a delayed release (DR) portion comprising a drug, wherein the drug consists of about 10 mg doxycycline, in which the DR portion is in the form of pellets coated with at least one enteric polymer; and

    (iii) one or more pharmaceutically acceptable excipients.

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