Method and apparatus for treatment of congestive heart disease

• US 7,758,531 B2
• Filed: 03/02/2007
• Issued: 07/20/2010
• Est. Priority Date: 03/02/2006
• Status: Active Grant

• Current Assignee: Vinod Patel
• Original Assignee: Vinod Patel
• Inventors: Patel, Vinod
• Primary Examiner(s): Zalukaeva; Tatyana
• Assistant Examiner(s): Hanrahan; Benedict L
• Application Number:
  US11/681,533
• Publication Number:
  US 20070208291A1
• Time in Patent Office: 1,236 Days
• Field of Search: 604/4.01, 604/9
• US Class Current: 604/4.01
• CPC Class Codes: A61M 1/3613 Reperfusion, e.g. of the coronary vessels, e.g. retroperfusion
• CPC Class Codes: A61M 2210/1082 Kidney
• CPC Class Codes: A61M 60/13 by means of a catheter allowing explantation, e.g. catheter pumps temporarily introduced via the vascular system
• CPC Class Codes: A61M 60/135 inside a blood vessel, e.g. using grafting
• CPC Class Codes: A61M 60/148 in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
• CPC Class Codes: A61M 60/237 the blood flow through the rotating member having mainly axial components, e.g. axial flow pumps
• CPC Class Codes: A61M 60/33 of kidneys
• CPC Class Codes: A61M 60/414 transmitted by a rotating cable, e.g. for blood pumps mounted on a catheter
• CPC Class Codes: A61M 60/515 Regulation using real-time patient data
• CPC Class Codes: A61M 60/531 using blood pressure data, e.g. from blood pressure sensors
• CPC Class Codes: A61M 60/546 of blood flow, e.g. by adapting rotor speed
• CPC Class Codes: A61M 60/554 of blood pressure
• CPC Class Codes: A61M 60/833 Occluders for preventing backflow
• CPC Class Codes: A61M 60/865 Devices for guiding or inserting pumps or pumping devices into the patient's body

Abstract

In one aspect, the present invention is directed to an apparatus and method for treating congestive heart failure that restores kidney renal functions by artificial perfusion of at least one kidney. In one aspect, a catheter inserted into the aorta of the patient has an outlet port that supplies the patient'"'"'s blood obtained from a patient'"'"'s aorta into an adjoining renal artery of the patient to perfuse the kidney. The catheter comprises a rotor housed inside a portion of the catheter to supply the blood to the kidney at a desired pressure. The restoration of kidney function assists the heart by removing excess fluid, urine and toxin from the patient, and by normalizing the patient'"'"'s renin-angiotensin system and other neurohormonal substances.

Claims

1. A method of perfusing a kidney of a patient with the patient'"'"'s blood, comprising:

providing a catheter comprising;

a conduit;

an inlet region defining at least one inlet port, a first end of the inlet port connected to a distal end of the conduit;

an outlet region defining an outlet port;

a lumen extending between the at least one inlet port and the outlet port;

a rotor mounted therein the inlet portion proximate the at least one inlet port, wherein the rotor is configured for selective rotation to pump fluid at a desired pressure from the at least one inlet port and out of the outlet port; and

a wire connected to the bottom end of the rotor such that rotation of the wire imparts a complementary rotation of the rotor, wherein the wire is sheathed at least partially by the conduit;

providing a power source that is operatively coupled to the wire;

advancing the catheter percutaneously and transluminally along a guidewire to dispose the at least one inlet port in a source of arterial blood proximate the patient'"'"'s renal artery;

inserting a portion of the outlet region into a portion of the renal artery while maintaining blood flow through the source of arterial blood and the renal artery;

engaging the outlet region within the patient'"'"'s renal artery by selectively occluding the renal artery such that blood exiting the lumen through the outlet port is substantially blocked from flowing out of the renal artery; and

selectively actuating the power source to control a pressure and a rate of blood flow through the lumen and into the renal artery of the kidney.

2. The method of claim 1, wherein the rotor is an axial rotor.

3. The method of claim 1, wherein the outlet region is flexible.

4. The method of claim 3, wherein the inlet region is less flexible than the outlet region.

5. The method of claim 1, further comprising a mount that is positioned therein first end of the inlet region and is configured to prevent retrograde blood flow into the conduit from the inlet region.

6. The method of claim 5, wherein the rotor is configured for rotational movement about a longitudinal axis of the mount.

7. The method of claim 1, wherein one of the patient'"'"'s kidneys is perfused and a second kidney of the patient is not perfused.

8. The method of claim 1, further comprising controlling the pressure of the blood delivered to the outlet port such that the pressure is within a normal autoregulatory range of a perfusion pressure for the kidney.

9. The method of claim 1, further comprising controlling a pressure of the blood delivered to the outlet port such that the pressure is higher than the normal autoregulatory range but lower than the pressure that will cause barotrauma of the kidney.

10. The method of claim 8 or 9, further comprising monitoring a pressure of the fluid proximate the outlet port of the catheter.

11. The method of claim 10, wherein the pressure being monitored is the blood pressure within the renal artery proximate the outlet port.

12. The method of claim 1, further comprising determining a baseline renal function by monitoring a urine output of the patient.

13. The method of claim 1, further comprising determining a baseline renal function by monitoring a blood pressure of the patient.

14. The method of claim 1, further comprising determining a baseline renal function by monitoring at least one hormonal level of the patient.

15. The method of claim 1, wherein the source of arterial blood is the patient'"'"'s aorta.