Diclofenac formulations and methods of use

  • US 7,759,394 B2
  • Filed: 06/16/2006
  • Issued: 07/20/2010
  • Est. Priority Date: 06/17/2005
  • Status: Active Grant
First Claim
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1. A method of treating migraine associated with phonophobia and photophobia in a human patient within two hours of administration comprising:

  • a) providing a liquid formulation comprising about 50 mg. of diclofenac or a pharmaceutically acceptable salt thereof in combination with an alkali metal carbonate or bicarbonate, wherein said formulation;

    i) is provided as a powder formulation and dissolved or suspended in water immediately before administration, or as a liquid formulation that is ingested with or without further mixing;

    ii) optionally has been found to achieve a maximum plasma concentration (Cmax) (arithmetic mean) of from about 1500 to about 2500 ng/ml; and

    iii) has been found to achieve a time to maximum plasma concentration (tmax) (arithmetic mean) in from about 10 to about 25 minutes;

    b) orally administering said formulation to a patient suffering from migraine associated with photophobia and phonophobia, andc) thereby relieving said photophobia and said phonophobia in said patient within two hours of administration.

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