Versatile high load concentrate compositions for control of ecto- parasites

• US 7,763,267 B2
• Filed: 05/17/2006
• Issued: 07/27/2010
• Est. Priority Date: 05/24/2005
• Status: Expired due to Fees

• Current Assignee: Nihon Nohyaku Co., Ltd.
• Original Assignee: Wyeth LLC (Pfizer Inc.)
• Inventors: Albright, Robert B., Sabnis, Shobhan
• Primary Examiner(s): Richter; Johann R
• Assistant Examiner(s): SULLIVAN, DANIELLE D
• Application Number:
  US11/435,684
• Publication Number:
  US 20060269585A1
• Time in Patent Office: 1,532 Days
• Field of Search: 514/522, 424/407, 424/405
• US Class Current: 424/407
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/02 containing liquids as carriers, diluents or solvents
• CPC Class Codes: A01N 25/30 characterised by the surfactants
• CPC Class Codes: A01N 47/34 containing the groups , e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
• CPC Class Codes: A61K 31/175 having the group , >N—C(O)—N=N— or , e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
• CPC Class Codes: A61K 47/44 Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin synthetic glycerides, e.g. medium-chain triglycerides, A61K47/14
• CPC Class Codes: A61K 9/0017 Non-human animal skin, e.g. pour-on, spot-on
• CPC Class Codes: A61K 9/08 Solutions composition of solutions A61K47/00
• CPC Class Codes: A61P 33/00 Antiparasitic agents
• CPC Class Codes: A61P 33/14 Ectoparasiticides, e.g. scabicides

Abstract

High load concentrate compositions comprising metaflumizone, an optional bridging agent, a surfactant, and a suitable carrier solvent. These compositions may be topically administered to animals, and are useful for preventing or treating ectoparasitic infestations in warm-blooded animals for prolonged periods of time. Additionally, they may be further diluted to provide other types of formulations useable for both topical and oral administration.

Claims

1. A composition for topical administration which comprises on a weight to volume basis:

about 5% to about 25% of metaflumizone;

about 2% to about 15% of a surfactant selected from an alcohol alkoxylate surfactant, nonylphenol ethoxylate surfactant or polyoxyl 35 castor oil surfactant; and

about 50% to 80% of a carrier solvent.

2. The composition according to claim 1, which comprises about 15% to 25% metaflumizone.

3. The composition according to claim 1 wherein the surfactant is an alcohol alkoxylate surfactant.

4. The composition according to claim 2 wherein the surfactant is a nonylphenol ethoxylate surfactant.

5. The composition according to claim 1 wherein the surfactant is present at a level of about 2% to about 8% w/v.

6. The composition according to claim 2 wherein the surfactant is present at a level of about 2% to about 8% w/v.

7. The composition according to claim 1 wherein the composition further comprises a bridging agent.

8. The composition according to claim 7 wherein the bridging agent is dimethyl sulfoxide.

9. The composition according to claim 1 wherein the carrier solvent is γ

-hexylactone.

10. The composition according to claim 2 wherein the carrier solvent is γ

-hexalactone.

11. The composition according to claim 1 wherein the carrier solvent is 1-methoxy-2-propyl acetate.

12. The composition according to claim 1 which additionally contains up to 2% of one or more preservatives, colorants, antioxidants, or stabilizers.

13. A method for preventing or treating ectoparasitic infection or infestation in a warm-blooded animal which method comprises topically administering to the animal effective amount of a composition according to claim 1.

14. The method according to claim 13 wherein the animal is selected from the group consisting of a cow, a sheep, a horse, a camel, a deer, a swine, a goat, a dog, a cat, and a bird.

15. The method according to claim 13 wherein the composition comprises about 5% to about 25% metaflumizone;

about 10% of a bridging agent;

about 2% to about 8% surfactant; and

about 50% to about 60% carrier solvent.

16. The method according to claim 13 wherein the composition comprises γ

-hexylactone as the carrier solvent.

17. The method according to claim 13 wherein the composition is further diluted for use as a pour-on composition.

18. The method according to claim 16 wherein the composition further comprises 1-methoxy-2-propyl acetate.

19. The method according to claim 13 wherein the composition is further diluted for use as a spray or feed/water additive.

20. A method for preventing or treating ectoparasitic infection or infestation in a warm-blooded animal which method comprises topically administering to the animal an effective amount of a pour-on composition, comprising:

the composition according to claim 1; and

a diluent.