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Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders

  • US 7,763,420 B2
  • Filed: 07/11/2007
  • Issued: 07/27/2010
  • Est. Priority Date: 07/11/2006
  • Status: Active Grant
First Claim
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1. A method for detecting a site of proliferation or a proliferative condition in a subject, comprising:

  • administering an E. coli strain Nissle bacterium to a subject, wherein;

    the subject has, is at risk of having or is suspected of having a proliferative condition; and

    the Nissle bacterium expresses or accumulates a detectable molecule or a molecule that induces or produces a detectable signal; and

    after a sufficient time for the Nissle bacterium to accumulate in proliferating tissues, detecting the detectable molecule or detectable signal to detect accumulation of Nissle bacterium in the subject, whereby detection of the Nissle bacterium indicates the site of proliferation or proliferative condition.

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