Low oxygen in vivo analyte sensor
First Claim
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1. A continuous glucose sensor system comprising:
- an implantable body comprising an electrode configured to measure a glucose level in a host;
a membrane disposed over the electrode, wherein the membrane comprises a resistance domain configured to limit transport of glucose to the electrode and an enzyme configured to catalyze a reaction of glucose and oxygen; and
sensor electronics operably connected to the electrode and configured to measure a current produced by the electrode with substantial linearity at glucose concentrations of to about 400 mg/dL in a fluid with an oxygen concentration of less than about 0.3 mg/L.
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Abstract
The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous and subcutaneous measurement of glucose in a host.
902 Citations
31 Claims
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1. A continuous glucose sensor system comprising:
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an implantable body comprising an electrode configured to measure a glucose level in a host; a membrane disposed over the electrode, wherein the membrane comprises a resistance domain configured to limit transport of glucose to the electrode and an enzyme configured to catalyze a reaction of glucose and oxygen; and sensor electronics operably connected to the electrode and configured to measure a current produced by the electrode with substantial linearity at glucose concentrations of to about 400 mg/dL in a fluid with an oxygen concentration of less than about 0.3 mg/L. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A continuous glucose sensor system comprising:
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an implantable body comprising an electrode configured to measure a glucose level in a host; a membrane disposed over the electrode, wherein the membrane comprises a resistance domain configured to limit transport of glucose to the electrode and an enzyme configured to catalyze a reaction of glucose and oxygen; and a sensor electronics unit operably connected to the electrode and configured to measure a current produced by the electrode with substantial linearity at glucose concentrations of up to about 400 mg/dL in a fluid with an oxygen concentration of less than about 0.6 mg/L, wherein the system is configured such that less than about 1 μ
g of enzyme is consumed over 7 days of continuous operation. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22)
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23. A continuous glucose sensor system comprising:
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an implantable body comprising an electrode configured to measure a glucose level in a host; a membrane disposed over the electrode, wherein the membrane comprises a resistance domain configured to limit transport of glucose to the electrode and an enzyme configured to catalyze a reaction of glucose and oxygen; and a sensor electronics unit operably connected to the electrode and configured to measure a current produced by the electrode with substantial linearity at glucose concentrations of up to about 400 mg/dL in a fluid with an oxygen concentration of less than about 0.6 mg/L, wherein the sensor system is configured to have, in operation, a sensitivity of from about 5 pA/mg/dL to about 25 pA/mg/dL. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31)
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Specification