Monoclonal antibodies that recognize epitopes of amyloid-beta
First Claim
1. A monoclonal antibody which specifically binds to monomeric, oligomeric or polymeric forms of amyloid-β
- , wherein;
(i) the CDR 1 of the light chain variable region of the monoclonal antibody has the amino acid sequence of SEQ ID NO;
23;
(ii) the CDR2 of the light chain variable region of the monoclonal antibody has the amino acid sequence of SEQ ID NO;
24;
(iii) the CDR3 of the light chain variable region of the monoclonal antibody has the amino acid sequence of SEQ ID NO;
25;
(iv) the CDR1 of the heavy chain variable region of the monoclonal antibody has the amino acid sequence of SEQ ID NO;
26;
(v) the CDR2 of the heavy chain variable region of the monoclonal antibody has the amino acid sequence of SEQ ID NO;
27; and
(vi) the CDR3 of the heavy chain variable region of the monoclonal antibody has the amino acid sequence of SEQ ID NO;
28.
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Abstract
The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer'"'"'s disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer'"'"'s Disease (AD).
186 Citations
15 Claims
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1. A monoclonal antibody which specifically binds to monomeric, oligomeric or polymeric forms of amyloid-β
- , wherein;
(i) the CDR 1 of the light chain variable region of the monoclonal antibody has the amino acid sequence of SEQ ID NO;
23;(ii) the CDR2 of the light chain variable region of the monoclonal antibody has the amino acid sequence of SEQ ID NO;
24;(iii) the CDR3 of the light chain variable region of the monoclonal antibody has the amino acid sequence of SEQ ID NO;
25;(iv) the CDR1 of the heavy chain variable region of the monoclonal antibody has the amino acid sequence of SEQ ID NO;
26;(v) the CDR2 of the heavy chain variable region of the monoclonal antibody has the amino acid sequence of SEQ ID NO;
27; and(vi) the CDR3 of the heavy chain variable region of the monoclonal antibody has the amino acid sequence of SEQ ID NO;
28. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- , wherein;
-
10. A monoclonal antibody produced by the hybridoma cell line FP 12H3-C2, deposited as DSM ACC2750.
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11. The hybridoma cell line FP 12H3-C2, deposited as DSM ACC2750.
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12. A monoclonal antibody which specifically binds to monomeric, oligomeric or polymeric forms of amyloid-β
- , wherein the CDR1 of the light chain has the amino acid sequence of SEQ ID NO;
23;
the CDR2 of the light chain has the amino acid sequence of SEQ ID NO;
24; and
the CDR3 of the light chain has the amino acid sequence of SEQ ID NO;
25.
- , wherein the CDR1 of the light chain has the amino acid sequence of SEQ ID NO;
-
13. A monoclonal antibody which specifically binds to monomeric, oligomeric or polymeric forms of amyloid-β
- , wherein the CDR1 of the heavy chain has the amino acid sequence of SEQ ID NO;
26;
the CDR2 of the heavy chain has the amino acid sequence of SEQ ID NO;
27; and
the CDR3 of the heavy chain has the amino acid sequence of SEQ ID NO;
28.
- , wherein the CDR1 of the heavy chain has the amino acid sequence of SEQ ID NO;
-
14. A monoclonal antibody which specifically binds to monomeric, oligomeric or polymeric forms of amyloid-β
- , wherein the light chain variable region has the amino acid sequence of SEQ ID NO;
7.
- , wherein the light chain variable region has the amino acid sequence of SEQ ID NO;
-
15. A monoclonal antibody which specifically binds to monomeric, oligomeric or polymeric forms of amyloid-β
- , wherein the heavy chain variable region has the amino acid sequence of SEQ ID NO;
8.
- , wherein the heavy chain variable region has the amino acid sequence of SEQ ID NO;
Specification