Implantable cardiac device with ischemia response capability
First Claim
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1. A cardiac device, comprising:
- one or more sensing channels for sensing cardiac activity;
one or more physiological sensors for sensing one or more variables related to cardiac ischemia;
a therapy channel for delivering therapy to the heart;
a controller for controlling the delivery of therapy in response to the sensed cardiac activity; and
,wherein the controller is programmed to;
collect a plurality of parameters associated with cardiac ischemia from the sensing channels and/or physiological sensors, where the plurality of parameters are designated X1 through Xn;
compute a vector-valued composite ischemia function that maps the plurality of parameters X1 through Xn to a vector with a plurality of components designated Y1 through Ym that characterize the ischemia by;
performing a regression analysis of historical values of the parameters and episodes of known ischemia, determining weighting coefficients from said analysis for each component of the vector-valued composite ischemia function, and computing each component of the vector-valued composite ischemia function as a weighted sum of one or more of the plurality of parameters using said weighting coefficients; and
,adjust the manner in which the therapy is delivered by mapping the vector-valued composite ischemia function to a plurality of device behavior modifications designated Z1 through Zk.
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Abstract
A cardiac device is described with the capability of detecting cardiac ischemia using multiple sensing modalities. The device may be configured to modify its behavior in delivering therapies to treat bradycardia or tachyarrhythmias in response to detection of cardiac ischemia.
68 Citations
39 Claims
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1. A cardiac device, comprising:
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one or more sensing channels for sensing cardiac activity; one or more physiological sensors for sensing one or more variables related to cardiac ischemia; a therapy channel for delivering therapy to the heart; a controller for controlling the delivery of therapy in response to the sensed cardiac activity; and
,wherein the controller is programmed to; collect a plurality of parameters associated with cardiac ischemia from the sensing channels and/or physiological sensors, where the plurality of parameters are designated X1 through Xn; compute a vector-valued composite ischemia function that maps the plurality of parameters X1 through Xn to a vector with a plurality of components designated Y1 through Ym that characterize the ischemia by;
performing a regression analysis of historical values of the parameters and episodes of known ischemia, determining weighting coefficients from said analysis for each component of the vector-valued composite ischemia function, and computing each component of the vector-valued composite ischemia function as a weighted sum of one or more of the plurality of parameters using said weighting coefficients; and
,adjust the manner in which the therapy is delivered by mapping the vector-valued composite ischemia function to a plurality of device behavior modifications designated Z1 through Zk. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method, comprising:
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sensing cardiac activity; delivering therapy to the heart in response to the sensed cardiac activity; sensing a plurality of parameters associated with cardiac ischemia; collecting a plurality of parameters associated with cardiac ischemia from the sensing channels and/or physiological sensors, where the plurality of parameters are designated X1 through Xn; computing a vector-valued composite ischemia function that maps the plurality of parameters X1 through Xn to a vector with a plurality of components designated Y1 through Ym that characterize the ischemia by;
performing a regression analysis of historical values of the parameters and episodes of known ischemia, determining weighting coefficients from said analysis for each component of the vector-valued composite ischemia function, and computing each component of the vector-valued composite ischemia function as a weighted sum of one or more of the plurality of parameters using said weighting coefficients; and
,adjusting the manner in which the therapy is delivered by mapping the vector-valued composite ischemia function to a plurality of device behavior modifications designated Z1 through Zk. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
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Specification