System and method for quantifying the dynamic response of a target system

• US 7,778,693 B2
• Filed: 04/07/2003
• Issued: 08/17/2010
• Est. Priority Date: 04/06/2002
• Status: Active Grant

• Current Assignee: United States Department Of Health And Human Services
• Original Assignee: United States Department Of Health And Human Services
• Inventors: Barbour, Randall L., Pei, Yaling
• Primary Examiner(s): Casler; Brian
• Assistant Examiner(s): KISH, JAMES M
• Application Number:
  US10/408,510
• Publication Number:
  US 20040039268A1
• Time in Patent Office: 2,689 Days
• Field of Search: 600/328, 600/473, 600/475
• US Class Current: 600/473
• CPC Class Codes: A61B 5/0091 for mammography
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/4312 Breast evaluation or disorder diagnosis A61B5/0091 takes precedence
• CPC Class Codes: A61B 5/4884 inducing physiological or psychological stress, e.g. applications for stress testing
• CPC Class Codes: A61B 5/726 using Wavelet transforms

Abstract

A time series of optical tomography data is obtained for a target tissue site in a human (or animal), using an optical wavelength, such as near infrared, at which hemoglobin is absorptive, to observe properties of the vasculature of the human. The data may be compared to baseline data of a corresponding tissue site, e.g., from a healthy human, or from another, corresponding tissue site of the human. For example, a suspected cancerous breast of a human may be compared to a known healthy breast to detect differences in the vasculature. Measures may be made of flow, oxygen supply/demand imbalance, and evidence of altered regulation of the peripheral effector mechanism. The function of the target tissue site may be analyzed, along with the coordinated interaction between multiple sites of the target system. A provocation may be administered to identify surrogate markers of an underlying state or process.

Claims

1. A method for assessing tissue function in a subject human or animal, comprising:

obtaining simultaneously a time series of optical tomography data from a first tissue site and a second tissue site of the subject human or animal, the first tissue site and the second tissue site being located at different areas of the subject human or animal, wherein the time series of optical tomography data from the first tissue site and the second tissue site identify temporal variations in at least one hemoglobin signal by illuminating a radiation at a wavelength at which hemoglobin is a principal absorbing species in the first and second tissues;

comparing the time series of optical tomography data from the first tissue site to the time series of corresponding optical tomography data from the second tissue site;

deriving a first time series of optical tomography images from the time series of optical tomography data from the first tissue site;

deriving a second time series of optical tomography images from the time series of optical tomography data from the second tissue site;

assessing differential responses or coordinated responses from the first tissue site and the second tissue site by determining a functional property of a vasculature through examination of said temporal variations in said at least one hemoglobin signal; and

generating a real-time 3D image based on said determining of said functional property of said vasculature, wherein image contrast is provided by employing said temporal variations in said at least one hemoglobin signal.

2. The method of claim 1, wherein the comparing step further comprises comparing phase differences in the optical tomography data or differences in hemoglobin states between the first and second tissue sites.

3. The method of claim 1, wherein the comparing step further comprises comparing a modulation amplitude of the optical tomography data as a function of carrier frequency for the first and second tissue sites.

4. The method of claim 1, wherein the comparing step further comprises comparing variations in the optical tomography data for the first and second tissue sites at a frequency band associated with a vascular beat frequency of the subject human or animal.

5. The method of claim 1, wherein the second tissue site is from a baseline human or animal that is known to be healthy.

6. The method of claim 1, further comprising:

provoking said vasculature before or during the obtaining of the time series of optical tomography data therefrom.

7. The method of claim 6, wherein the step of provoking further includes provoking using physiological maneuver, metabolic maneuver, metabolic maneuver, dietary conditioning, or physical conditioning, or combinations thereof.

8. The method of claim 1, wherein the first tissue site and the second tissue site are contralateral areas of said subject human or animal.

9. The method of claim 1, wherein said at least one hemoglobin signal includes a hemoglobin level or an oxygen level of hemoglobin.

10. The method of claim 1, further comprising provoking vasculature of the subject human or animal during said obtaining step to assess differential responses or coordinated responses from the first tissue site and the second tissue site.

11. The method of claim 1, wherein the deriving steps include reconstructing the first time series of optical tomography images and the second time series of optical tomography images by solving a perturbation equation using respectively the time series of optical tomography data from a first tissue site and the time series of optical tomography data from the second tissue site.

12. A method for assessing tissue function in a subject human or animal, comprising:

obtaining simultaneously first and second time series of optical tomography data from first and second tissue sites of the subject human or animal, the first tissue site and the second tissue site being located at different areas, wherein the first and second time series of optical tomography data from the first and second tissue sites identify temporal variations in at least one hemoglobin signal by illuminating a radiation at a wavelength at which hemoglobin is a principal absorbing species in the first and second tissues;

comparing the first time series of optical tomography data to the second time series of optical tomography data to assess tissue function of the tissue site;

deriving a first time series of optical tomography images from the first time series of optical tomography data; and

deriving a second time series of optical tomography images from the second time series of optical tomography data;

assessing differential responses or coordinated responses from the first tissue site and the second tissue site by determining a functional property of a vasculature through examination of said temporal variations in said at least one hemoglobin signal; and

generating a real-time 3D image based on said determining of said functional property of said vasculature, wherein image contrast is provided by employing said temporal variations in said at least one hemoglobin signal.

13. The method of claim 12, wherein the comparing step further comprises comparing phase differences of the optical tomography data in the first and second time series.

14. The method of claim 12, wherein the comparing step further comprises comparing hemoglobin states for the first and second time series.

15. The method of claim 12, wherein the comparing step further comprises comparing a modulation amplitude of the optical tomography data as a function of carrier frequency for the first and second time series.

16. The method of claim 12, wherein the comparing step further comprises comparing variations in the optical tomography data for the first and second time series at a frequency band associated with a vascular beat frequency of the subject human or animal.

17. The method of claim 12, further comprising:

provoking said vasculature before or during the obtaining of the first time series of optical tomography data therefrom.

18. The method of claim 12, further comprising provoking vasculature of the subject human or animal during said obtaining step using physiological maneuver, metabolic maneuver, pharmacological maneuver, dietary conditioning, or physical conditioning or combinations thereof, to assess differential responses or coordinated responses from the first tissue site and the second tissue site.

19. The method of claim 12, wherein the deriving steps include reconstructing the first time series of optical tomography images and the second time series of optical tomography images by solving a perturbation equation using respectively the time series of optical tomography data from a first tissue site and the time series of optical tomography data from the second tissue site.

20. A method for assessing tissue function in a subject human or animal, comprising:

obtaining simultaneously without using contrast agent a time series of optical tomography data from a first tissue site and a second tissue site of the subject human or animal, the first tissue site and the second tissue site being located at different areas of the subject human or animal, wherein the first and second time series of optical tomography data from the first and second tissue sites identify temporal variations in at least one hemoglobin signal by illuminating a radiation at a wavelength at which hemoglobin is a principal absorbing species in the first and second tissues;

provoking a vasculature of the subject human or animal during said obtaining step using physiological maneuver, metabolic maneuver, pharmacological maneuver, dietary conditioning, or physical conditioning or combinations thereof;

comparing the time series of optical tomography data from the first tissue site to a time series of corresponding optical tomography data from a second tissue site;

deriving a first time series of optical tomography images from the time series of optical tomography data from the first tissue site;

deriving a second time series of optical tomography images from the time series of optical tomography data from the second tissue site;

assessing differential responses or coordinated responses from the first tissue site and the second tissue site by determining a functional property of said vasculature through examination of said temporal variations in said at least one hemoglobin signal; and

generating a real-time 3D image based on said determining of said functional property of said vasculature, wherein image contrast is provided by employing said temporal variations in said at least one hemoglobin signal.

21. The method of claim 20, wherein the deriving steps include reconstructing the first time series of optical tomography images and the second time series of optical tomography images by solving a perturbation equation using respectively the time series of optical tomography data from a first tissue site and the time series of optical tomography data from the second tissue site.