Reduction of heart rate variability by parasympathetic stimulation
First Claim
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1. Apparatus comprising:
- an electrode device, configured to be coupled to a site of a subject selected from the group consisting of;
a vagus nerve, and an epicardial fat pad;
a cardiac monitor, configured to detect a cardiac signal; and
a control unit, configured to;
drive the electrode device to apply a current to the site in respective pulse bursts in each of a plurality of cardiac cycles of the subject, andconfigure the current to reduce heart rate variability of the subject below a baseline heart rate variability of the subject which corresponds to the subject'"'"'s heart rate variability when the current is not applied, by initiating the applying of each burst after a delay of 30 to 200 milliseconds following an R-wave of the cardiac signal.
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Abstract
Apparatus is provided that includes an electrode device, adapted to be coupled to a vagus nerve of a subject, and a control unit, adapted to drive the electrode device to apply to the vagus nerve a current that reduces heart rate variability of the subject. Also provided is a method comprising applying to a vagus nerve of a subject a current that reduces heart rate variability of the subject.
347 Citations
72 Claims
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1. Apparatus comprising:
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an electrode device, configured to be coupled to a site of a subject selected from the group consisting of;
a vagus nerve, and an epicardial fat pad;a cardiac monitor, configured to detect a cardiac signal; and a control unit, configured to; drive the electrode device to apply a current to the site in respective pulse bursts in each of a plurality of cardiac cycles of the subject, and configure the current to reduce heart rate variability of the subject below a baseline heart rate variability of the subject which corresponds to the subject'"'"'s heart rate variability when the current is not applied, by initiating the applying of each burst after a delay of 30 to 200 milliseconds following an R-wave of the cardiac signal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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39. A method comprising:
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identifying a subject as being appropriate for reduction of heart rate variability of the subject below a baseline heart rate variability of the subject which corresponds to the subject'"'"'s heart rate variability when parasympathetic stimulation is not applied; applying a current to a site of the subject selected from the group consisting of;
a vagus nerve, and an epicardial fat pad; andin response to the identifying, treating a condition of the subject by reducing the heart rate variability below the baseline heart rate variability, by configuring the current. - View Dependent Claims (40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71)
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72. A method comprising:
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detecting a cardiac signal of the subject; applying a current to a site of a subject in respective pulse bursts in each of a plurality of cardiac cycles of the subject, the site selected from the group consisting of;
a vagus nerve, and an epicardial fat pad; andconfiguring the current to reduce heart rate variability of the subject below a baseline heart rate variability of the subject which corresponds to the subject'"'"'s heart rate variability when the current is not applied, by initiating the applying of each burst after a delay of 30 to 200 milliseconds following an R-wave of the cardiac signal.
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Specification