Methods, systems, and associated implantable devices for detecting radiation in patients undergoing treatment for cancer
First Claim
1. A method for monitoring a tumor site of a patient undergoing treatment for cancer, comprising:
- administering a radiolabeled agent to the patient subsequent to a chemotherapeutic treatment;
detecting in vivo from at least one wireless implantable sensor configured to reside adjacent solid tissue at a tumor site, a radiation signal in the solid tissue at the tumor site responsive to the administering step;
telemetrically relaying the detected radiation signal to a location external of the patient'"'"'s body;
electronically determining uptake of the radiolabeled agent in the solid tissue based on the relayed detected radiation signal; and
evaluating a patient specific response to the chemotherapeutic treatment and/or a likelihood of clinical efficacy of a subsequent cancer treatment for the patient based on the determined uptake.
3 Assignments
0 Petitions
Accused Products
Abstract
Methods and systems for evaluating external beam radiation therapy delivered to a subject include: (a) placing at least one wireless implantable sensor in a first subject at a target location; (b) administering a first dose of radiation therapy into the first subject; (c) obtaining radiation data from the at least one wireless implantable sensor; and (d) calculating a radiation dose amount received by the first subject at the target location based on the radiation data obtained from the at least one wireless sensor during and/or after exposure to the first administered dose of radiation to determine and/or verify a dose amount of radiation delivered to the target location.
134 Citations
30 Claims
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1. A method for monitoring a tumor site of a patient undergoing treatment for cancer, comprising:
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administering a radiolabeled agent to the patient subsequent to a chemotherapeutic treatment; detecting in vivo from at least one wireless implantable sensor configured to reside adjacent solid tissue at a tumor site, a radiation signal in the solid tissue at the tumor site responsive to the administering step; telemetrically relaying the detected radiation signal to a location external of the patient'"'"'s body; electronically determining uptake of the radiolabeled agent in the solid tissue based on the relayed detected radiation signal; and evaluating a patient specific response to the chemotherapeutic treatment and/or a likelihood of clinical efficacy of a subsequent cancer treatment for the patient based on the determined uptake. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A detection system for a tumor site, comprising:
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at least one wireless chronically implantable radiation sensor configured for in vivo operation, the at least one sensor being configured to detect radiation from a radiolabeled agent administered after a chemotherapeutic treatment in solid tissue proximate a tumor treatment site in the body, wherein the at least one sensor is inductively powered; and an external reader configured to inductively power and telemetrically communicate with the at least one radiation sensor to wirelessly receive radiation signal data associated with radiation detected by the at least one radiation sensor; and a processor in the reader or in communication with the reader configured to monitor the received radiation data over time to determine uptake of the radiolabeled agent at the tumor site and to evaluate a patient-specific tumor response to the chemotherapeutic treatment. - View Dependent Claims (12, 13, 14)
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15. A computer program product for evaluating a cancer treatment regimen in a cancer patient, said computer program product comprising a computer readable non-transitory medium having computer readable program code embodied therein, the computer readable program code comprising:
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computer readable program code for operating at least one wireless sensor to obtain a plurality of radiation signals over time corresponding to radiation in solid tissue at a tumor site responsive to an administration of a radiolabeled material which is administered after a chemotherapeutic treatment; computer readable program code for determining uptake of the radiolabeled material in the solid tissue at the tumor site using the obtained radiation signals; and computer readable program code for evaluating at least one of the following based on the determined uptake;
(a) cell proliferation of the tumor site;
(b) a patient specific response to the chemotherapeutic treatment; and
(c) a likelihood of clinical efficacy of a subsequent planned cancer treatment for the patient. - View Dependent Claims (16)
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17. A detection system for detecting in vivo radiation in a body of an oncology patient, comprising:
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at least one wireless radiation sensor configured for in vivo operation, the at least one sensor being configured to detect radiation in solid tissue proximate a tumor treatment site in the body of the oncology patient in response to a radiolabeled agent administered after a chemotherapeutic treatment, wherein the at least one sensor is inductively powered; and an external reader configured to telemetrically communicate with the at least one radiation sensor, the reader being configured to wirelessly receive radiation signal data associated with radiation detected by the at least one sensor proximate the tumor treatment site over a desired time period; and a processor in the reader or in communication with the reader and a physician computer, the processor configured to determine uptake of the radiolabeled agent associated with the received radiation signal data and generate at least one of the following based on the determined uptake;
(a) cell proliferation data of the tumor treatment site;
(b) the patient'"'"'s response to the chemotherapeutic treatment; and
(c) a likelihood of clinical efficacy of the chemotherapeutic treatment and/or a subsequent cancer treatment. - View Dependent Claims (18, 19, 20, 21)
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22. A method for monitoring a tumor site of a patient, comprising:
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detecting from at least one sensor adjacent or in solid tissue at the tumor site a radiation signal in response to a radiolabeled substance administered after a chemotherapeutic treatment; relaying the detected radiation signal to a location external of the patient'"'"'s body; and electronically determining at least one tumor physiologic parameter based on the relayed radiation signal; and evaluating the patient'"'"'s response to the chemotherapeutic treatment and/or whether to administer a subsequent treatment to the patient based on the determined tumor parameter. - View Dependent Claims (23, 24, 25)
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26. A system for monitoring a tumor site in an oncology patient, comprising:
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at least one wireless implantable radiation sensor configured to be positioned adjacent solid tissue proximate a tumor treatment site, the at least one sensor being configured to detect radiation associated with radiolabeled agent in the solid tissue proximate the tumor treatment site in the body, wherein the radiolabeled agent is administered to the patient after a chemotherapeutic treatment; and an external reader operably associated with the at least one radiation sensor, the reader being configured to wirelessly receive radiation signal data from the at least one sensor, wherein said reader comprises a processor configured to monitor the detected radiation at the tumor site over time to determine uptake of the radiolabeled agent at the tumor treatment site to assess at least one of the following tumor physiology parameters subsequent to the chemotherapeutic treatment;
(a) cell proliferation status;
(b) cell kinetics; and
(c) a cell proliferation rate. - View Dependent Claims (27, 28)
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29. A system for monitoring a tumor site in an oncology patient, comprising:
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at least one wireless sensor configured to reside adjacent to and detect a radiation signal and an oxygen signal from cells in solid tissue proximate a tumor treatment site in the body; and an external reader operably associated with the at least one sensor, the reader being configured to wirelessly receive signal data from the at least one sensor including radiation signal data obtained over a desired time associated with a radiolabeled agent administered to the patient after a chemotherapeutic treatment; and a processor in the reader or in communication with the reader configured to determine uptake of the radiolabeled agent in the solid tissue at the tumor treatment site using the radiation signal data obtained over time to assess at least one of the following tumor site physiology or biologic parameters after the chemotherapeutic treatment;
(a) cell proliferation status;
(b) cell kinetics; and
(c) a cell proliferation rate. - View Dependent Claims (30)
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Specification