Evaluating mixtures of low molecular weight heparins by chain profiles or chain mapping

  • US 7,790,466 B1
  • Filed: 01/25/2008
  • Issued: 09/07/2010
  • Est. Priority Date: 01/26/2007
  • Status: Active Grant
First Claim
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1. A method of analyzing an enoxaparin preparation, comprising:

  • providing an isolated tetrasaccharide fraction from a size fractioned enoxaparin preparation;

    analyzing the tetrasaccharide fraction using strong anion exchange high performance liquid chromatography (HPLC) to determine if one or more chains shown in the following table is present or is present in amount identified in the following table;

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