Active implantable medical devices, notably for pacing, resynchronization, defibrillation and/or cardioversion, having improved diagnosis of the patient's clinical status

• US 7,792,582 B2
• Filed: 11/24/2006
• Issued: 09/07/2010
• Est. Priority Date: 11/23/2005
• Status: Active Grant

• Current Assignee: Sorin CRM USA (MicroPort Scientific Corp.)
• Original Assignee: Sorin CRM SAS
• Inventors: Casset, Cyrille
• Primary Examiner(s): Getzow; Scott M
• Assistant Examiner(s): Dietrich; Joseph M
• Application Number:
  US11/563,123
• Publication Number:
  US 20070150016A1
• Time in Patent Office: 1,383 Days
• Field of Search: 607/5, 607/9, 607/19
• US Class Current: 607/19
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/1118 Determining activity level
• CPC Class Codes: A61N 1/3702 Physiological parameters A61N1/365 takes precedence; evoked response A61N1/371

Abstract

An active implantable medical device, preferably a device for pacing, resynchronization, defibrillation and/or cardioversion of a patient, that includes functionality that assists in the diagnosis of the patient'"'"'s clinical status. This devices comprises circuits (10, 12) for measuring one physiologic parameter, preferably minute ventilation (VE), and circuits (14, 16) for measuring a physical parameter, preferably acceleration (G), control logic (18) for discriminating between activity and rest phases of the patient, and analysis circuits (20-28), to process and combine these signals and memorize (store in memory) the obtained results in the form of a data history. The analysis will establish characteristics providing, for successive dates, representative values, for a given period of time, of the physical signal and physiologic signal during activity phases of the patient, and/or of the physiologic signal during rest phases. These circuits search for remarkable dates for each of the characteristics and allocate specific indices of clinical status respective to each of the periods comprised between the remarkable dates, then combined the specific thus obtained into one single composite index.

Claims

1. An active implantable medical device for pacing, resynchronization, defibrillation and/or cardioversion, or an active implant intended to diagnose a cardiac rhythm disorder, comprising:

means for measuring a predominantly physiologic corporeal parameter and providing a physiologic signal representative thereof;

means for measuring a predominantly physical corporeal parameter and providing a physical signal representative thereof;

means for discriminating a patient status of a patient between rest phases and activity phases, operating in response to said physiologic signal and said physical signal,

means for providing a status index corresponding to the patient status;

memory for memorizing the physiologic signal, the physical signal and the status index; and

means for analyzing the patient status, responsive to the physiologic signal, the physical signal and the status index,

wherein said means for analysis comprises;

first means for providing characteristic values as a function of time for the physical signal during the activity phases of the patient, the physiologic signal during the activity phases of the patient and/or the physiologic signal during the rest phases of the patient,

second means for determining a plurality of remarkable dates from the characteristic values, the plurality of remarkable dates defining endpoints of a plurality of characteristic periods and time period between two successive remarkable dates defining a characteristic period of the plurality of characteristic periods,

third means for allocating a specific index of specific indices of the patient status respectively to each characteristic period of the plurality of characteristic periods, wherein the specific index is a numerical value indicating improvement, degradation, or stability of the patient status of each characteristic period with respect to the patient status of the immediately preceding characteristic period, and

fourth means for combining one or more said specific indices into a composite index.

2. The device of claim 1, wherein said second means further comprises means for performing a multiple linearization, said means for performing a multiple linearization transforms each characteristic value of said characteristic values into a continuous series of line segments, each line segment of said line segments having a pair of endpoints and a slope, said pair of endpoints representing one of said plurality of remarkable dates.

3. The device of claim 2, wherein each line segment of the continuous series of line segments defines each characteristic period of the characteristic periods.

4. The device of claim 2, wherein said means for performing a multiple linearization iteratively operates through an application of a regression formula.

5. The device of claim 4, wherein said means for performing a multiple linearization calculates absolute values of the variance between said continuous series of line segments and said characteristic values and defines a remarkable date of said plurality of remarkable dates if the sum of the absolute values of the variance is greater than a first predetermined threshold value.

6. The device of claim 5, wherein said means for performing a multiple linearization defines said remarkable date of said plurality of remarkable dates only if each of the absolute values of the variance between said continuous series of line segments and said characteristic values is less than a second predetermined threshold.

7. The device of claim 2, wherein said third means evaluates the slope of said line segments and allocates the corresponding specific index as a function of said slope.

8. The device of claim 1, wherein said fourth means implements a prerecorded truth table providing, for each possible combination of said specific indices, a corresponding value of said composite index.

9. The device of claim 1, wherein said first means calculates moving averages of said physical signal during said activity phases and establishes characteristic values based upon the calculated moving averages.

10. The device of claim 1, wherein said first means calculates moving averages of said physiologic signal during said activity phases and establishes characteristic values based upon the calculated moving averages.

11. The device of claim 1, wherein said first means calculates moving averages of said physiologic signal during said rest phases and establishes characteristic values based upon the calculated moving averages.

12. The device of claim 1, wherein said specific indices and said composite index are periodically re-evaluated.