Devices and methods for percutaneously treating aortic valve stenosis

• US 7,803,131 B2
• Filed: 12/22/2005
• Issued: 09/28/2010
• Est. Priority Date: 07/17/2003
• Status: Active Grant

• Current Assignee: Cardinal Health Switzerland 515 GmbH (Cardinal Health, Inc.)
• Original Assignee: Cordis Corporation (Cardinal Health, Inc.)
• Inventors: Laird, Rob, Helkowski, Rick
• Primary Examiner(s): Lucchesi; Nicholas D
• Assistant Examiner(s): Bouchelle; Laura A
• Application Number:
  US11/318,058
• Publication Number:
  US 20060161133A1
• Time in Patent Office: 1,741 Days
• Field of Search: 60410101-10202, 604/103.07, 604/103.13, 606/194, 606/200
• US Class Current: 604/101.01
• CPC Class Codes: A61B 17/12045 double occlusion, e.g. during anastomosis
• CPC Class Codes: A61B 17/12131 characterised by the type of occluding device
• CPC Class Codes: A61B 17/12136 Balloons
• CPC Class Codes: A61B 17/22 Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for dilators A61M29/00
• CPC Class Codes: A61B 2017/12127 Double occlusion, e.g. for creating blood-free anastomosis site
• CPC Class Codes: A61B 2017/22054 with two balloons
• CPC Class Codes: A61B 2017/22067 Blocking; Occlusion A61B2017/22054 takes precedence
• CPC Class Codes: A61B 2017/22084 stone- or thrombus-dissolving
• CPC Class Codes: A61M 2025/1052 for temporarily occluding a vessel for isolating a sector
• CPC Class Codes: A61M 2025/109 having balloons for removing solid matters, e.g. by grasping or scraping plaque, thrombus or other matters that obstruct the flow
• CPC Class Codes: A61M 2025/1095 with perfusion means for enabling blood circulation while the balloon is in an inflated state or in a deflated state, e.g. permanent by-pass within catheter shaft
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00

Abstract

Devices and methods for their use in percutaneously increasing the aortic valve flow of a stenotic aortic valve are provided. The subject devices include an aortic valve isolation element, a shunt element and an aortic valve flushing element. Also provided are systems and kits that include the subject devices and can be employed in practicing the subject methods. The subject devices, methods, systems and kits find use in treating conditions associated with the presence of stenotic aortic valves.

Claims

1. A device comprising:

(a) a valve isolation element that includes;

(i) a ventricular side aortic valve occlusion element configured to prevent fluid flow from the valve to the ascending aorta, the ventricular side aortic valve occlusion element comprising a funnel structure, the funnel structure including a self-expanding ring and a thin membrane impervious to fluid flow; and

(ii) an ascending aorta occlusion element, the occlusion element including an occlusion bell comprising an expandable wire scaffold;

(b) a shunt element having first and second ends and configured to provide blood flow through a region of isolation proximate the aortic valve, the funnel structure being positioned at a distal end of the shunt to anchor the device in place, the shunt element passing through the central regions of the ventricular side aortic valve occlusion element and the ascending aorta occlusion element and having at least one inflow port and at least one outflow port with a one way valve; and

(c) an aortic valve flushing element comprising a dissolution fluid introduction element and an aspiration element configured to maintain the volume and pressure around the valve substantially constant.

2. The device according to claim 1, wherein said fluid introducing element is in fluid communication with a source of stenotic dissolution fluid.

3. The device according to claim 2, wherein said stenotic dissolution fluid is an acidic dissolution fluid.

4. The device according to claim 1, wherein said device further includes a fluid flow diverter element.

5. The device according to claim 1, wherein said device is configured for percutaneous delivery to a target site.

6. The device according to claim 1, wherein said device further comprises an integrated introducer.