Compounds useful for modulating abnormal cell proliferation

• US 7,807,719 B2
• Filed: 09/14/2004
• Issued: 10/05/2010
• Est. Priority Date: 09/14/2004
• Status: Active Grant

• Current Assignee: Hospital For SICK Children
• Original Assignee: Chaim Roifman, Olga Rounova, Peter Demin, Thomas Grunberger
• Inventors: Rounova, Olga, Demin, Peter, Grunberger, Tom, Roifman, Chaim
• Primary Examiner(s): Chung; Susannah
• Application Number:
  US10/940,009
• Publication Number:
  US 20060058297A1
• Time in Patent Office: 2,212 Days
• Field of Search: 514/557, 514/561, 562/405, 564/179
• US Class Current: 514/557
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 35/02 specific for leukemia
• CPC Class Codes: C07C 255/41 the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
• CPC Class Codes: C07D 213/40 Acylated substituent nitrogen atom
• CPC Class Codes: C07D 213/57 Nitriles
• CPC Class Codes: C07D 307/54 Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• CPC Class Codes: C07D 333/24 Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Abstract

There is described compounds of Formulae I, II, III, IV and V. The compounds of Formulae I, II, III, IV and/or V are useful: in therapeutic methods and compositions for modulating cell proliferation, in diagnostic assays and as research tools.

Claims

1. A compound of Formula I and a salt thereof:

8. A pharmaceutical composition comprising the compound defined in claim 1, together with a pharmaceutically acceptable carrier therefor.

2. 4-Chloro-2-cyano-5-phenyl-penta-2E,4Z-dienoic acid 3,4-dihydroxybenzylamide (CRC-47).

3. A compound of Formula II and a salt thereof:

4. 2-Cyano-5-furan-2-yl-penta-2E,4E-dienoic acid 3,4-dihydroxybenzylamide (CRH-48).

5. 2-Cyano-5-pyridin-3-yl-penta-2E,4E-dienoic acid 3,4-dihydroxybenzylamide (CRH-58).

6. 2-Cyano-5-pyridin-3-yl-penta-2E,4E-dienoic acid benzylamide (CRH-59).

7. 2-Cyano-5-thiophen-2-yl-penta-2E,4E-dienoic acid 3,4-dihydroxybenzylamide (CRH-60).