Device for automatic regulation of the concentration of glucose in the blood of a diabetes patient

• US 7,811,246 B2
• Filed: 10/26/2006
• Issued: 10/12/2010
• Est. Priority Date: 10/26/2005
• Status: Active Grant

• Current Assignee: Inreda Diabetic B.V.
• Original Assignee: Inreda Diabetic B.V.
• Inventors: Koops, Robin
• Primary Examiner(s): Lucchesi; Nicholas D
• Assistant Examiner(s): Ranade; Diva
• Application Number:
  US12/091,841
• Publication Number:
  US 20090099507A1
• Time in Patent Office: 1,447 Days
• Field of Search: 604 65- 67
• US Class Current: 604/65
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61M 39/24 Check- or non-return valves
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

A device for regulating the concentration of glucose in the blood of a diabetes patient includes a measuring component for measuring the concentration, a pump component for selectively introducing glucagon, or glucose instead, or insulin into the body of the patient, for instance by way of at least one hypodermic needle to be inserted into the body of the patient; and a control component which receives signals from the measuring component which are representative of the concentration and which control the pump component on the basis of at least one reference value for the concentration pre-entered into the control component and a program; wherein the device is embodied such that the measuring component and the pump component can be in substantially permanent contact with the bodily fluid or the blood of a patient.

Claims

1. A device for regulating the concentration of glucose in the blood of a diabetes patient, the device comprising:

a measuring component adapted for measuring the concentration of glucose in the blood of the diabetes patient;

a pump component adapted for selectively introducing glucagon into a body of the patient or introducing glucose into the bloodstream of the patient, or introducing insulin into the body of the patient via at least one hypodermic needle to be inserted into the body of the patient; and

a control component which receives signals from the measuring component which are representative of said concentration, and which controls the pump component on the basis of at least one reference value for said concentration pre-entered into the control component and a program such that said concentration is regulated, wherein the program incorporates an adjustable glucagon injection curve represented by a formula 1 (ml(E)/fall mmol/l/unit of time) and an adjustable insulin injection curve represented by formula 2 (ml(E)/rise mmol/l/unit of time) corresponding to an amount of glucagon or insulin, respectively introduced into the body of the patient, and the nominal concentration of the glucose in the blood of the patient as a reaction thereto,

wherein the device is embodied such that the measuring component and the pump component can be in substantially permanent contact with a bodily fluid or the blood of a patient.

2. The device as claimed in claim 1, wherein the control component stores in a memory, information relating to the introduced quantity of insulin or glucagon respectively, and in each successive case compares this information to the concentration of the glucose in the blood of the patient as a reaction thereto, also store this latter information in a memory, and use this latter information for metering the insulin or glucagon respectively, such that the control component is of a learning type.

3. The device as claimed in claim 1, wherein the pump component comprises two pumps, one for glucagon or glucose and one for insulin, and an individual hypodermic needle is added to each pump.

4. The device as claimed in claim 1, wherein the pump component comprises two pumps, one for glucagon or glucose and one for insulin, and one shared hypodermic needle with two passages is added to the two pumps, wherein one passage serves for transport of glucagon or glucose and one for transport of insulin.

5. The device as claimed in claim 1, wherein the measuring component comprises a glucose sensor to be placed in the body of the patient.

6. The device as claimed in claim 5, wherein the glucose sensor is carried by a hypodermic needle.