Heterocyclic NF-κB inhibitors
First Claim
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1. A compound of the general formula (III) or a salt, or a stereoisomer thereof,
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Abstract
The present invention relates to compounds of the general formula (I) and salts and physiologically functional derivatives thereof,
wherein
- R1 is independently hydrogen; alkyl, cycloalkyl, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl or substituted arylalkyl;
- R2 is independently —NR3R4,
- R3 is independently alkyl, cycloalkyl, alkoxy, alkylamine, —OH, —SH, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl,
- R4 is independently alkyl, cycloalkyl, alkoxy, alkylamine, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl;
- R5 is independently H, COR6, CO2R6, SOR6, SO3R6, alkyl, cycloalkyl, alkoxy, —NH2, alkylamine, —NR7COR6, halogen, —OH, —SH, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl;
- R6 is independently H, alkyl, cycloalkyl, —NH2, alkylamine, aryl or heteroaryl;
- R7 is independently H, alkyl, cycloalkyl, alkoxy, —OH, —SH, alkylthio, hydroxyalkyl, aryl, or heteroaryl;
- p is 0, or 1;
- q is 0, or 1;
- X is CO, or SO2.
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9 Claims
- 1. A compound of the general formula (III) or a salt, or a stereoisomer thereof,
Specification