Methods for modulating thermal and mechanical properties of coatings on implantable devices

• US 7,820,732 B2
• Filed: 04/30/2004
• Issued: 10/26/2010
• Est. Priority Date: 04/30/2004
• Status: Expired due to Fees

• Current Assignee: Advanced Cardiovascular Systems Incorporated
• Original Assignee: Advanced Cardiovascular Systems Incorporated
• Inventors: Borgaonkor, Harshad, Tang, Yiwen, Pacetti, Stephen D., Hossainy, Syed Faiyaz Ahmed, DesNoyer, Jessica Renee
• Primary Examiner(s): Landau; Sharmila Gollamudi
• Assistant Examiner(s): Welter; Rachael E
• Application Number:
  US10/835,656
• Publication Number:
  US 20050245637A1
• Time in Patent Office: 2,370 Days
• Field of Search: 424/423
• US Class Current: 523/113
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials

Abstract

Methods for modulating and enhancing thermal and mechanical properties and biocompatibilities of coatings on implantable devices are disclosed. Implantable devices containing the enhanced thermal and mechanical properties and biocompatibilities are also described. The implantable devices can be used to treat a medical condition such as vulnerable plaque or restenosis.

Claims

1. A method of modulating thermal, mechanical, and surface properties of a coating and applying the coating on an implantable device, comprising:

(1) Providing a first polymer, wherein said first polymer has a glass transition temperature less than or equal to 37°

C. and is selected from a poly(ester amide), poly(glycerol sebacic acid), and a low Tg PolyAspirin,

(2) Reacting said first polymer with a chemical stiffening agent, wherein the agent is an aromatic diol,

(3) Obtaining a second polymer having a Tg higher than the Tg of the first polymer,

(4) Forming a coating comprising the second polymer, and

(5) Applying the coating on an implantable device.

2. The method of claim 1 wherein the coating further comprises a bioactive agent.

3. The method of claim 1 wherein the coating further comprises a bioactive agent selected from the group consisting of zotarolimus, paclitaxel, docetaxel, tacrolimus, pimecrolimus, batimastat, mycophenolic acid, clobetasol, dexamethasone, rapamycin, 40-O-(2-hydroxy)ethyl-rapamycin, 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, 40-O-tetrazole-rapamycin, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl, and combinations thereof.