Laser scanning digital camera with simplified optics and potential for multiply scattered light imaging

• US 7,831,106 B2
• Filed: 05/30/2007
• Issued: 11/09/2010
• Est. Priority Date: 05/31/2006
• Status: Active Grant

• Current Assignee: Indiana University Research & Technology Corporation (Indiana University)
• Original Assignee: Indiana University Research & Technology Corporation (Indiana University)
• Inventors: Petrig, Benno, Elsner, Ann E.
• Primary Examiner(s): Kassa; Yosef
• Application Number:
  US12/302,531
• Publication Number:
  US 20090244482A1
• Time in Patent Office: 1,259 Days
• Field of Search: 382/254, 382/274, 382/275, 382/282
• US Class Current: 382/254
• CPC Class Codes: A61B 3/1025 for confocal scanning
• CPC Class Codes: A61B 3/156 for blocking

Abstract

A portable, lightweight digital imaging device uses a slit scanning arrangement to obtain an image of the eye, in particular the retina. The scanning arrangement reduces the amount of target area illuminated at a time, thereby reducing the amount of unwanted light scatter and providing a higher contrast image. A detection arrangement receives the light remitted from the retinal plane and produces an image. The device is operable under battery power and ambient light conditions, such as outdoor or room lighting. The device is noncontact and does not require that the pupil of the eye be dilated with drops. The device can be used by personnel who do not have specialized training in the eye, such as emergency personnel, pediatricians, general practitioners, or volunteer or otherwise unskilled screening personnel. Images can be viewed in the device or transmitted to a remote location. The device can also be used to provide images of the anterior segment of the eye, or other small structures. Visible wavelength light is not required to produce images of most important structures in the retina, thereby increasing the comfort and safety of the device. Flexible and moderate cost confocal and fluorescent imaging, multiply scattered light images, and image sharpening are further functionalities possible with the device.

Claims

1. A digital retinal imaging device comprising:

a. an illumination source;

b. a scanning element operable to move a portion of an illumination pathway created by the illumination source with respect to a target;

c. at least one slit within the illumination pathway of the illumination source; and

d. a two dimensional complementary metal-oxide-semiconductor (“

CMOS”

) detector chip having a rolling shutter functionality.

2. The digital retinal imaging device of claim 1, wherein the device lacks a lens array and mechanical aperture.

3. The device of claim 1, further comprising an electronic or mechanical aperture within the illumination pathway operable to shape the illumination pathway.

4. The device of claim 1, wherein the illumination pathway is shaped by increasing or decreasing the width of a slit aperture, thereby resulting in an improved image quality for a resulting confocal image, multiply scattered light image, or sharpened image.

5. The device of claim 1, wherein an electronic aperture and a two dimensional detector array replaces the CMOS with rolling shutter.

6. The device of claim 1, wherein the illumination source is an infrared illumination source.

7. A digital retinal imaging device comprising:

a. an illumination source and scanning element operable to move the illumination source with respect to a target;

b. a detector array operable to detect and build a first image data set relative to the target, and further operable to detect and build a second image data set relative to the target;

c. a processor operable to utilize the first image data set and the second image data set such that each line comprising the first image data set is compared to a corresponding line on the second image data set in a weighted manner such that a sharpened image is created.

8. The digital retinal imaging device of claim 7, wherein the detector array is a complementary metal-oxide-semiconductor.

9. The digital retinal imaging device of claim 7, wherein the processor is further operable to utilize the first image data set and the second image data set such that each line comprising the first image data set is combined with a corresponding line in the second image data set in a weighted manner such that an improved signal to noise ratio is obtained by increasing a sampled area imaged by the device.

10. The device of claim 7, further comprising an electronic or mechanical aperture within the illumination pathway operable to shape the illumination pathway.

11. The device of claim 7, wherein the illumination pathway is shaped by increasing or decreasing the width of a slit aperture, thereby resulting in an improved image quality for a resulting confocal image, multiply scattered light image, or sharpened image.

12. The device of claim 7, wherein an electronic aperture and a two dimensional detector array replaces the CMOS with rolling shutter.

13. The device of claim 7, wherein the illumination source is an infrared illumination source.

14. A digital imaging device comprising:

a. an illumination source and a mechanism to cause a scanning motion of the illumination with respect to a target;

b. a CMOS array operable to select one or more leading lines or lagging lines with respect to the alignment with an optical axis of a beam from the illumination source;

c. a processor operable to combine the one or more leading lines and lagging lines selected and detected to create a multiply scattered image.

15. The device of claim 14, further comprising an electronic or mechanical aperture within the illumination pathway operable to shape the illumination pathway.

16. The device of claim 14, wherein the illumination pathway is shaped by increasing or decreasing the width of a slit aperture, thereby resulting in an improved image quality for a resulting confocal image, multiply scattered light image, or sharpened image.

17. The device of claim 14, wherein an electronic aperture and a two dimensional detector array replaces the CMOS with rolling shutter.

18. The device of claim 14, wherein the illumination source is an infrared illumination source.

19. The device of claim 14, operable to combine wherein the one or more leading lines and lagging lines are combined in a weighted manner.

20. The device of claim 19, wherein the one or more leading lines and lagging lines selected and detected are combined into an image in a weighted manner to obtain a confocal image.

21. The device of claim 20, wherein the resulting image is further modified by weighting the one or more leading lines and lagging lines in such a manner that signal to noise ratio, image contrast, and/or other image quality variables are maximized.

22. A device for digital retinal imaging, comprising:

a. an illumination source that fluoresces when excited, and operable to produce an illumination pathway;

b. a first detector array within the illumination pathway operable to detect wavelengths of irradiated energy reflected from a target within the illumination pathway;

c. a barrier filter operable to reject selected wavelengths such that only selected wavelengths reach the detector.

23. The device of claim 22, further comprising a second detector array operable to be synchronized to the first detector array such that stereo imaging, polarimetry and simultaneous indirect light imaging with a leading and lagging electronic aperture can be performed.