Methods and products for error determination of drug dose in pharmaceutical mixtures
First Claim
1. A program product for determining an error in an ingredient'"'"'s quantities in a multi-component pharmaceutical formula measured by multiple analytical instruments, said error being a value of variation of concentration for a validation under an assay standard, the program product including a computer readable computer program encoded in a non-transitory tangible storage medium, said program product employing the steps of:
- setting a computing mode according to a selection by a user on a type of error analysis;
receiving a value for a quantity of an ingredient of a composition to be measured by an instrument;
receiving a value for a sensitivity of the analytical instrument measuring the quantity of the ingredient;
repeating the two receiving steps for any remaining ingredients to be measured that compose the pharmaceutical formula;
executing an algorithm based on the following equations to relate;
the quantities of measurements and sensitivities of instruments to a value of variation of the final concentration of any ingredient in the pharmaceutical formula;
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Abstract
The present invention discloses a computer program and a method including an algorithm for computing the uncertainty of drug concentration in pharmaceutical dosage forms. The invention also provides a computer system, a website and an IC chip incorporating the program product. The invention determines the allowable sensitivity of the instruments measuring each of the components and the least allowable weight (LAW) within a maximum allowable error of each ingredient at the predetermined assay standard. The method and products allow the accurate error evaluation of drug dose in pharmaceutical mixtures and unit dosage forms, which may be composed of an infinite number of ingredients that are measured on multiple equipments of variable sensitivities. Thus this invention provides instant guidance on the pharmaceutical ingredient preparation.
10 Citations
5 Claims
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1. A program product for determining an error in an ingredient'"'"'s quantities in a multi-component pharmaceutical formula measured by multiple analytical instruments, said error being a value of variation of concentration for a validation under an assay standard, the program product including a computer readable computer program encoded in a non-transitory tangible storage medium, said program product employing the steps of:
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setting a computing mode according to a selection by a user on a type of error analysis; receiving a value for a quantity of an ingredient of a composition to be measured by an instrument; receiving a value for a sensitivity of the analytical instrument measuring the quantity of the ingredient; repeating the two receiving steps for any remaining ingredients to be measured that compose the pharmaceutical formula; executing an algorithm based on the following equations to relate;
the quantities of measurements and sensitivities of instruments to a value of variation of the final concentration of any ingredient in the pharmaceutical formula; - View Dependent Claims (2, 3, 4, 5)
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Specification