Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots

• US 7,837,997 B2
• Filed: 12/18/2006
• Issued: 11/23/2010
• Est. Priority Date: 05/21/1998
• Status: Expired due to Fees

• Current Assignee: Trustees Of The University Of Pennsylvania (University of Pennsylvania), University of Virginia Patent Foundation (University of Virginia)
• Original Assignee: Trustees Of The University Of Pennsylvania (University of Pennsylvania), University of Virginia Patent Foundation (University of Virginia)
• Inventors: Muzykantov, Vladimir R., Murciano, Juan Carlos, Taylor, Ronald P., Higazi, Abd Al-Roof, Cines, Douglas
• Primary Examiner(s): Borin; Michael
• Application Number:
  US11/640,737
• Publication Number:
  US 20080050389A1
• Time in Patent Office: 1,436 Days
• Field of Search: None
• US Class Current: 424/153.1
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 35/18 Erythrocytes haemoglobin A61K38/42
• CPC Class Codes: A61K 38/166 Streptokinase
• CPC Class Codes: A61K 38/177 Receptors; Cell surface antigens; Cell surface determinants
• CPC Class Codes: A61K 38/49 Urokinase; Tissue plasminogen activator
• CPC Class Codes: A61P 7/00 Drugs for disorders of the blood or the extracellular fluid
• CPC Class Codes: A61P 7/02 Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Abstract

Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots are provided wherein fibrinolytic or anticoagulant drugs are biocompatibly coupled to red blood cell carriers.

Claims

1. A composition comprising biotinylated plasminogen activator cross-linked monovalently to a biotinylated red blood cell carrier via streptavidin.

2. The composition according to claim 1, wherein the plasminogen activator is uPA or tPA.