Apparatus and method for delivering electrical signals to modify gene expression in cardiac tissue
First Claim
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1. A method for improving heart function comprising electrically modifying the expression in heart tissue of genes that effect cardiovascular system function using an electric field to intentionally both modify the expression and modify a cardiac function, wherein the field is applied to diseased cardiac cells in a heart in which they formed.
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Abstract
Method and apparatus (120) for modifying gene expression in cardiac muscle cells (110), by the application of electric fields.
378 Citations
52 Claims
- 1. A method for improving heart function comprising electrically modifying the expression in heart tissue of genes that effect cardiovascular system function using an electric field to intentionally both modify the expression and modify a cardiac function, wherein the field is applied to diseased cardiac cells in a heart in which they formed.
- 19. A method for treating heart failure comprising electrically modifying the expression in heart tissue of genes that effect cardiovascular system function using an electric field to intentionally both modify the expression and modify a cardiac function, wherein the field is applied to diseased cardiac cells in a heart in which they formed.
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24. A method of treating a patient with a cardiac related disease, comprising:
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determining a desired target gene expression profile in cardiac tissue; and applying a non-excitatory signal to the cardiac tissue to modify the gene expression in accordance with the desired target gene expression profile. - View Dependent Claims (25, 26)
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- 27. A method for improving heart function comprising electrically modifying the expression in heart tissue of genes that effect cardiovascular system function using an electric field that both modifies the expression over a long term and acutely improves cell function of said heart, wherein the non-excitatory signal is applied to diseased cardiac cells in a heart in which they formed.
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30. A method of treating a patient with heart failure, comprising:
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determining a desired target gene expression profile in cardiac tissue, said profile associated with improvement in cardiac failure; and applying a non-excitatory signal to the cardiac tissue to modify the gene expression in accordance with the desired target gene expression profile, wherein the non-excitatory signal is applied to diseased cardiac cells in a heart in which they formed. - View Dependent Claims (31, 32, 33, 34, 35, 36, 37, 38)
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39. A method of treating a patient with a diseased heart, comprising:
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(a) determining a desired target gene expression profile in in-vivo cardiac tissue of a diseased heart, said profile associated with improvement in cardiac function; and (b) applying an electrical signal to diseased cardiac cells formed in the diseased heart to modify the gene expression in accordance with the desired target gene expression profile. - View Dependent Claims (40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52)
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Specification