Systems and methods of blood-based therapies having a microfluidic membraneless exchange device

• US 7,850,633 B2
• Filed: 07/24/2009
• Issued: 12/14/2010
• Est. Priority Date: 03/14/2003
• Status: Expired due to Fees

• Current Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Original Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Inventors: West, Alan C., Leonard, Edward F., Shapley, Nina C., Tang, Zhongliang
• Primary Examiner(s): KIM, SUN U
• Application Number:
  US12/509,395
• Publication Number:
  US 20090292234A1
• Time in Patent Office: 508 Days
• Field of Search: 210/200, 210/201, 210/252, 210/258, 210/321.6, 210/456, 210/645, 210/646, 210/642, 210/643, 210/767, 210/805, 210/806, 422/100, 422/101, 422/104, 604/4.01, 604/5.01, 604/5.04, 604/6.09, 604/6.11, 604/6.16
• US Class Current: 604/5.04
• CPC Class Codes: A61M 1/14 Dialysis systems; Artificial kidneys; Blood oxygenators semi-permeable membranes characterised by the material, manufacturing processes therefor B01D71/00 ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/32 Oxygenators without membranes
• CPC Class Codes: A61M 1/3482 by filtrating the filtrate using another cross-flow filter, e.g. a membrane filter
• CPC Class Codes: A61M 1/3621 Extra-corporeal blood circuits single-needle circuits A61M1/30
• CPC Class Codes: A61M 2206/11 Laminar flow
• CPC Class Codes: B01D 11/04 of solutions which are liquid
• CPC Class Codes: B01D 11/0496 by extraction in microfluidic devices
• CPC Class Codes: B01D 61/243 Dialysis
• CPC Class Codes: B01D 61/244 comprising multiple dialysis steps
• CPC Class Codes: B01D 61/28 Apparatus therefor
• CPC Class Codes: B01L 3/5027 by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip B01L3/5023 takes precedence; micromixers B01F33/30; microreactors for synthesis B01J19/0093; microcapillary devices in general B81B1/00
• CPC Class Codes: G01N 2001/4016 being a selective membrane, e.g. dialysis or osmosis
• CPC Class Codes: Y10T 436/255 including use of a solid sorbent, semipermeable membrane, or liquid extraction

Abstract

The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of ‘small’ molecules, ‘middle’ molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.

Claims

1. A method of performing a blood treatment, comprising:

attaching venous and arterial blood lines of a patient'"'"'s blood tubing set to a first respective outlet and a first respective inlet of a membraneless channel;

attaching a first inlet and a first outlet of a membrane filter device to a second respective outlet and a second respective inlet of the membraneless channel such that a recirculating channel connecting the second respective outlet and the second respective inlet is defined, the recirculating channel being continuous and uninterrupted by a membrane;

attaching a second inlet of the membrane filter device to a source of dialysate;

permitting toxins and water to pass from the membraneless channel through a membrane of the membrane filter device to a second outlet of the membrane filter device;

returning components of the patient'"'"'s blood passing in the recirculating channel back to the patient'"'"'s blood;

disconnecting the source of dialysate after a first treatment while leaving the venous and arterial blood lines attached to the first respective outlet and the first respective inlet of the membraneless channel; and

repeating the attaching the second inlet to a source of dialysate, the permitting, and the returning so as to perform a second treatment.

2. The method of performing a blood treatment according to claim 1, wherein the permitting includes flowing blood in the membraneless channel and fluid in the recirculating channel such that the components move from the blood flow into the recirculating channel flow without passing through a membrane.

3. The method of performing a blood treatment according to claim 1, wherein the permitting includes flowing blood in the membraneless channel and flowing fluid in the recirculating channel such that the toxins and water move from the blood flow into the recirculating channel flow without passing through a membrane.

4. The method of performing a blood treatment according to claim 1, further comprising, after the disconnecting and before the repeating, flowing blood in the membraneless channel and fluid in the recirculating channel.

5. The method of performing a blood treatment according to claim 1, wherein said components of the patient'"'"'s blood include blood proteins.

6. The method of performing a blood treatment according to claim 1, wherein said components of the patient'"'"'s blood include albumin.

7. A method of performing a blood treatment on a patient, the method comprising:

connecting a membraneless channel device to both the patient and a membrane filter device such that a blood flow path of the membraneless channel device is coupled to respective inlet and outlet lines of a patient'"'"'s blood tubing set and a recirculating flow path of the membraneless channel device is coupled to a respective inlet and outlet of the membrane filter device;

connecting the membrane filter device to a source of dialysate;

co-flowing blood from the patient along the blood flow path and fluid from the membrane filter device along the recirculating flow path without a membrane between the paths such that toxins, water, and blood components move from the blood flow into the fluid flow and exit the membraneless channel device;

flowing dialysate from said source along a side of a membrane in the membrane filter device such that toxins and water in the fluid flow exiting the membraneless channel device move across the membrane into the dialysate flow; and

disconnecting the membrane filter device from the source of dialystate.

8. The method of performing a blood treatment according to claim 7, wherein, the co-flowing blood and fluid and the flowing dialysate occur at a same time.

9. The method of performing a blood treatment according to claim 7, further comprising, after the disconnecting:

continuing to co-flow blood from the patient along the blood flow path and fluid from the membrane filter device along the recirculating flow path without a membrane between the paths,

wherein the membrane filter device is not connected to a source of dialysate during said continuing.

10. The method of performing a blood treatment according to claim 7, wherein the blood components in the exiting fluid flow are returned to the membraneless channel.

11. The method of performing a blood treatment according to claim 10, wherein the co-flowing blood and fluid is such that blood components from the exiting fluid flow are returned to the flowing blood.

12. The method of performing a blood treatment according to claim 7, wherein the blood components include albumin.