Expandable medical device for delivery of beneficial agent
First Claim
1. An expandable medical device comprising:
- a plurality of struts interconnected to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter; and
a beneficial agent and carrier affixed to the plurality of struts and configured and arranged to control the release kinetics of the beneficial agent to surrounding tissue, wherein the release kinetics include an increasing agent release profile.
3 Assignments
0 Petitions
Accused Products
Abstract
An expandable medical device has a plurality of elongated struts joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. At least one of the plurality of struts includes at least one opening extending at least partially through a thickness of the strut. A beneficial agent is loaded into the opening within the strut in layers to achieve desired temporal release kinetics of the agent. Alternatively, the beneficial agent is loaded in a shape which is configured to achieve the desired agent delivery profile. A wide variety of delivery profiles can be achieved including zero order, pulsatile, increasing, decreasing, sinusoidal, and other delivery profiles.
483 Citations
34 Claims
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1. An expandable medical device comprising:
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a plurality of struts interconnected to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter; and a beneficial agent and carrier affixed to the plurality of struts and configured and arranged to control the release kinetics of the beneficial agent to surrounding tissue, wherein the release kinetics include an increasing agent release profile. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. An expandable medical device comprising:
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a plurality of struts interconnected to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter; a beneficial agent and biodegradable carrier affixed to the plurality of struts and configured and arranged to control the temporal release kinetics of the beneficial agent to surrounding tissue, wherein said release kinetics include on increasing agent release profile and 100% discharge of the beneficial agent from the device. - View Dependent Claims (15, 16, 17, 18, 19, 20)
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21. A method of forming an expandable medical device comprising:
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providing an expandable medical device with a plurality of struts interconnected to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter; applying a solution of beneficial agent, biodegradable carrier layer, and solvent to the device and evaporating the solvent to form a solid beneficial agent and carrier layer; and wherein the beneficial agent and carrier layer are configured and arranged to release the beneficial agent with an increasing agent release profile and 100% discharge of the beneficial agent from the device. - View Dependent Claims (22, 23, 24, 25, 26, 27)
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28. An expandable medical device comprising:
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a plurality of struts interconnected to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter; a beneficial agent and carrier affixed to the plurality of struts and configured and arranged to control the temporal release kinetics of the beneficial agent to surrounding tissue, wherein release kinetics include a two part release profile with both an increasing agent release profile and a decreasing agent release profile. - View Dependent Claims (29, 30, 31, 32, 33, 34)
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Specification